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ORIGINAL RESEARCH article

Front. Public Health
Sec. Infectious Diseases: Epidemiology and Prevention
Volume 12 - 2024 | doi: 10.3389/fpubh.2024.1533765
This article is part of the Research Topic Microbial Resistance and Infection Control in Public Health Care Setting View all 4 articles

Characteristics and risk factors for infection and mortality caused by Klebsiella pneumoniae in patients with acute pancreatitis Author names and affiliations

Provisionally accepted
Jing Chen Jing Chen Qian Xiang Qian Xiang Jia-Yu Wu Jia-Yu Wu *Xiao-Jia Zheng Xiao-Jia Zheng *Xiao-Yan Jiang Xiao-Yan Jiang *
  • Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China

The final, formatted version of the article will be published soon.

    The purpose of this study is to investigate the risk factors for carbapenem-resistant Klebsiella pneumoniae (CRKP) infection and death of K. pneumoniae infections in acute pancreatitis (AP) patients. Methods: This was a retrospective analysis of AP patients with K. pneumoniae infection between January 2019 and April 2024. Logistic regression model was used to determine the risk factors for acquisition of CRKP. Cox proportional hazards regression model was used to identify risk factors for mortality of K. pneumoniae infection. Results: A total of one hundred and thirteen AP patients experienced K. pneumoniae infections, including 66 with CRKP infection and 47 with CSKP infection. The mortality rate of these patients was 36.3%, with a significantly higher mortality rate in the CRKP group than in the CSKP group (P<0.001). Only mechanical ventilation (OR=2.301; 95% CI 1.02-5.20; P=0.045) was the independent risk factor for CRKP infection in patients with AP. Surgery (HR 0.38; 95% CI 0.20-0.75; P=0.005) and mechanical ventilation (HR 2.93; 95% CI 1.10-7.82; P=0.032) were the independent risk factors associated with mortality of K. pneumoniae infection in patients with AP. Conclusion: Klebsiella pneumoniae infection has become a threat to patients with AP. Therefore, implementing preventive and control measures based on risk factors is crucial for the prognosis.

    Keywords: acute pancreatitis, Klebsiella pneumoniae, Carbapenem resistance, risk factor, Mortality

    Received: 24 Nov 2024; Accepted: 31 Dec 2024.

    Copyright: © 2024 Chen, Xiang, Wu, Zheng and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jia-Yu Wu, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China
    Xiao-Jia Zheng, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China
    Xiao-Yan Jiang, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China

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