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ORIGINAL RESEARCH article
Front. Public Health
Sec. Infectious Diseases: Epidemiology and Prevention
Volume 12 - 2024 |
doi: 10.3389/fpubh.2024.1523839
This article is part of the Research Topic Women in Science: Infectious Diseases: Epidemiology and Prevention 2023 View all 19 articles
Outcomes and Associated Factors of Cervical Human Papillomavirus Infection Among 608 Women in Shenzhen, China, 2018-2023
Provisionally accepted
Zhenghan Lv
1
Xuesen He
2*
Zhiju Li
2
Yue Yuan
2*
Xinyi Zhou
2*
Changqing Tu
2*
Yinqi Yang
2*
Yanshan Huang
2*
Lili Yin
1*
Huihui Chen
1*
Yanling Tao
3*- 1 Clinical Medical College of Shenzhen, Guangzhou University of Chinese Medicine, Shenzhen, China
- 2 Department of Preventive and Health Care, Longgang District Central Hospital of Shenzhen, Shenzhen, China
- 3 Longgang District Central Hospital of Shenzhen, Shenzhen, China
Objective: This study aimed to uncover the patterns of Human papillomavirus (HPV) infection outcomes in women and assess the risk factors that may affect these outcomes. Methods: A retrospective study was conducted on 608 women who tested positive for HPV-DNA during their initial visit to the outpatient department of Shenzhen Longgang Central Hospital from 2018 to 2023 and who had subsequent HPV-DNA testing as part of their post-visit monitoring. The monitoring intervals were every 6 months. The rank sum test was used to analyze ranked data. The Kaplan-Meier method was used to analyze the turning negative time. Univariate analysis was performed using the log-rank test, and multivariate analysis was performed using the Cox model to analyze independent risk factors. Results: The results showed that the median age was 40.00 years (interquartile 33.00–47.00 years), the total conversion rate of the HPV-negative patients was 38.98%, and the median conversion time of the HPV-negative patients was 8.95 months (interquartile 4.20–16.175 months). Age, infection status and type of health insurance were significantly correlated with HPV outcome (P<0.05). Conclusions: Among women infected with HPV, the overall rate of negative HPV infection was 38.93%, and the duration of negative conversion was 8.95 months. The study revealed that age, HPV infection status, and type of medical insurance are independent predictors of the persistence of negative HPV test outcomes.
Keywords: Human papillomavirus1, Outcome, prognosis2, clearance rate3, cervical lesions4, negative conversion5
Received: 06 Nov 2024; Accepted: 11 Dec 2024.
Copyright: © 2024 Lv, He, Li, Yuan, Zhou, Tu, Yang, Huang, Yin, Chen and Tao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xuesen He, Department of Preventive and Health Care, Longgang District Central Hospital of Shenzhen, Shenzhen, China
Yue Yuan, Department of Preventive and Health Care, Longgang District Central Hospital of Shenzhen, Shenzhen, China
Xinyi Zhou, Department of Preventive and Health Care, Longgang District Central Hospital of Shenzhen, Shenzhen, China
Changqing Tu, Department of Preventive and Health Care, Longgang District Central Hospital of Shenzhen, Shenzhen, China
Yinqi Yang, Department of Preventive and Health Care, Longgang District Central Hospital of Shenzhen, Shenzhen, China
Yanshan Huang, Department of Preventive and Health Care, Longgang District Central Hospital of Shenzhen, Shenzhen, China
Lili Yin, Clinical Medical College of Shenzhen, Guangzhou University of Chinese Medicine, Shenzhen, China
Huihui Chen, Clinical Medical College of Shenzhen, Guangzhou University of Chinese Medicine, Shenzhen, China
Yanling Tao, Longgang District Central Hospital of Shenzhen, Shenzhen, China
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