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ORIGINAL RESEARCH article

Front. Public Health
Sec. Aging and Public Health
Volume 12 - 2024 | doi: 10.3389/fpubh.2024.1516267

Systematic Analysis and Prediction of the Burden of Alzheimer's Disease and Other Dementias Caused by Hyperglycemia

Provisionally accepted
Dongying He Dongying He 1,2Yujin Tang Yujin Tang 2Manting Liu Manting Liu 3Xiaona Tian Xiaona Tian 4Lisi Zhou Lisi Zhou 3Yizhen Chen Yizhen Chen 5Xiaoxia Liu Xiaoxia Liu 1*
  • 1 Foshan Hospital of Traditional Chinese Medicine, Foshan, China
  • 2 Eighth Clinical Medical College, Guangzhou University of Chinese Medicine, Foshan, Guangdong Province, China
  • 3 Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
  • 4 Zhongshan People's Hospital (ZSPH), Zhongshan, Guangdong, China
  • 5 Jiangmen Wuyi Tranditional Chinese Medicine Hospital, Jiangmen, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Background: Alzheimer's disease and other dementias (ADOD) pose a significant and escalating global public health challenge, particularly among the aging populations. Emerging evidence has identified high fasting plasma glucose (HFPG) as a major modifiable risk factor for ADOD, linking impaired glucose metabolism to cognitive decline and neurodegeneration. Despite this association, the comprehensive impact of HFPG on the global burden of ADOD has not been fully elucidated. Understanding the extent to which HFPG contributes to ADOD is crucial for developing targeted interventions and optimizing healthcare resource allocation to address this growing concern.: Using Global Burden of Disease data (GBD 2021), we analyzed the global HFPG-related ADOD burden from 1990 to 2021 using an age-period-cohort framework and predicted trends for 2050. A Shiny platform was developed to visualize the disease burden and trends across 204 countries and regions. Results: In 2021, approximately 15% of ADOD deaths and disability-adjusted life years (DALYs) were attributed to HFPG, a 271.05% increase from 1990. The incidence rate rose from 47.07 to 66.42, indicating poor control. The mortality rate from HFPG-ADOD increased by 305.81%. The primary burden was among the 80-84 age group. Trends in ASDR and ASMR showed an increase across most SDI regions, except Low SDI. Decomposition analysis and the APC model indicated poor control in high SDI regions due to aging populations over the past five years. By 2050, the global prevalence is

    Keywords: disease burden, Dementia, Frontier analysis, predictive analysis, Alzheimer's disease

    Received: 24 Oct 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 He, Tang, Liu, Tian, Zhou, Chen and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiaoxia Liu, Foshan Hospital of Traditional Chinese Medicine, Foshan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.