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ORIGINAL RESEARCH article

Front. Public Health
Sec. Aging and Public Health
Volume 12 - 2024 | doi: 10.3389/fpubh.2024.1505066

Association Between Phenotypic Age and Mortality Risk in Individuals with Obesity: A Retrospective Cohort Study

Provisionally accepted
Yingxuan Huang Yingxuan Huang 1Apei Zhou Apei Zhou 1Yisen Huang Yisen Huang 1Yubin Wang Yubin Wang 1Xiaobo Liu Xiaobo Liu 2Xiaoqiang Liu Xiaoqiang Liu 1*
  • 1 Quanzhou First Hospital, Fujian Medical University, Quanzhou, China
  • 2 McGill University, Montreal, Quebec, Canada

The final, formatted version of the article will be published soon.

    Objective: This study investigates the association between phenotypic age acceleration (PAA) and all-cause and cause-specific mortality in obese individuals. Methods: Data were drawn from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018, including 9,925 obese adults (BMI ≥ 30 kg/m²). PAA, defined as phenotypic age exceeding chronological age, was assessed using clinical biomarkers.Kaplan-Meier survival analysis and Cox proportional hazards models were used to assess the relationship between PAA and all-cause, cardiovascular, and cancer mortality, adjusting for covariates such as age, gender, race, lifestyle, and health status. Subgroup and sensitivity analyses were performed to ensure the robustness of the findings. Results: During a median follow-up of 10.6 years, 1,537 deaths were recorded, including 419 from cardiovascular disease and 357 from cancer. PAA was significantly associated with all-cause mortality (HR = 1.84, 95% CI: 1.64-2.06), cardiovascular mortality (HR = 1.86, 95% CI: 1.50-2.31), and cancer mortality (HR = 1.47, 95% CI: 1.17-1.85). These associations remained significant after adjusting for multiple variables, and sensitivity analyses confirmed the robustness of the results. Conclusion: PAA is an independent predictor of all-cause, cardiovascular, and cancer mortality in obese individuals. This study highlights the importance of PAA in mortality risk assessment and health management in the obese population.

    Keywords: Phenotypic age acceleration, Obesity, All-cause mortality, cardiovascular disease, Cancer, NHANES

    Received: 02 Oct 2024; Accepted: 25 Nov 2024.

    Copyright: © 2024 Huang, Zhou, Huang, Wang, Liu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiaoqiang Liu, Quanzhou First Hospital, Fujian Medical University, Quanzhou, China

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