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SYSTEMATIC REVIEW article

Front. Public Health
Sec. Aging and Public Health
Volume 12 - 2024 | doi: 10.3389/fpubh.2024.1494291

Association between COPD and CKD: A Systematic Review and Meta-Analysis

Provisionally accepted
Zexin Liu Zexin Liu 1Zhimin Ma Zhimin Ma 1Chaowei Ding Chaowei Ding 2*
  • 1 Second Department of Respiratory and Critical Care Medicine, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
  • 2 Xiamen Hong'ai Hospital, Xiamen, China

The final, formatted version of the article will be published soon.

    OBJECTIVE: Chronic obstructive pulmonary disease (COPD) and chronic kidney disease (CKD) are significant global health issues with a well-established association between the two. This study aims to assess the risk of developing CKD in patients with COPD through systematic review and meta-analysis, and to explore the impact of CKD on the prognosis of COPD patients.A total of 23 studies were included in the analysis, comprising 11 studies on the risk of CKD in patients with COPD, 6 studies on the impact of CKD on the short-term all-cause mortality risk of patients with acute exacerbation of COPD (AECOPD), and 6 studies on the impact of CKD on the long-term all-cause mortality risk of COPD patients. The meta-analysis showed that the risk of developing CKD in COPD patients was significantly increased (OR 1.54, 95% CI: 1.28-1.84), and CKD significantly increased the short-term all-cause mortality risk in AECOPD patients (OR 1.53, 95% CI: 1.44-1.63) as well as the long-term all-cause mortality risk in COPD patients (OR 1.70, 95% CI: 1.35-2.15).We searched the PubMed, EMBASE, and Cochrane Library databases in accordance with the PRISMA guidelines, including studies from the inception of the databases through December 31, 2023, to identify research assessing the relationship between COPD and CKD. The quality of the studies was assessed using the Newcastle-Ottawa Scale (NOS). Data were analyzed using either a random effects model or a fixed effects model for the meta-analysis.This study establishes a significant association between COPD and CKD and reveals the adverse impact of CKD on the prognosis of COPD patients, which may provide important guidance for clinical practice.

    Keywords: chronic obstructive pulmonary disease, Chronic Kidney Disease, Systematic review, Meta-analysis, Comorbidity

    Received: 10 Sep 2024; Accepted: 27 Nov 2024.

    Copyright: © 2024 Liu, Ma and Ding. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chaowei Ding, Xiamen Hong'ai Hospital, Xiamen, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.