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ORIGINAL RESEARCH article

Front. Public Health
Sec. Environmental Health and Exposome
Volume 12 - 2024 | doi: 10.3389/fpubh.2024.1476953

Association between brominated flame retardants and periodontitis: a large-scale population-based study

Provisionally accepted
Hao Jiang Hao Jiang Jingwen Yin Jingwen Yin Meixiang Wang Meixiang Wang Aili Yuan Aili Yuan Jing Wu Jing Wu Yi Lu Yi Lu *
  • The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China

The final, formatted version of the article will be published soon.

    Background: The association between brominated flame retardants (BFRs) and periodontitis has remained unclear.Methods: This research included adult participants from NHANES cycles 2009-2014. Surveyweighted generalized linear regressions were used to explore the associations between BFR exposure and periodontitis. Ln-transformed BFRs were treated as quantitative variables and then divided into four quartiles for qualitative analysis. Restricted cubic splines (RCSs) were utilized to investigate potential nonlinear relationships. Quantile weighted quantile sum (WQS) regression and quantile gcomputation (QGC) analysis were performed to assess the overall effect of BFRs on periodontitis.Results: A total of 2,445 participants were included in this study. In the fully adjusted model, several ln-transformed BFR components were positively correlated with periodontitis: serum PBDE28, PBDE47, PBDE85, PBDE99, PBDE100, PBDE154, and PBB153. When expressed in quartiles, PBDE28, PBDE85, PBDE100, PBDE154, and PBB153 showed increased odds with periodontitis.We found significant nonlinear correlation between PBDE28, PBDE47, PBDE85, PBDE100, PBDE154, and PBB153 with periodontitis in the RCS regression. The WQS index for mixed BFR exposure was positively associated with periodontitis prevalence (OR: 1.52; 95% CI: 1.30-1.79, P < 0.001). Similarly, the QGC analysis showed a positive association between mixed BFR exposure and periodontitis prevalence (β: 1.29; 95% CI: 1.24-1.36, P < 0.001).Conclusion: This study indicates that overall exposure to BFRs is positively associated with the prevalence of periodontitis. Further research is needed to investigate the causal relationship and underlying mechanisms between BFRs and periodontitis.

    Keywords: Brominated flame retardants, Periodontitis, WQS, QGC, NHANES

    Received: 06 Aug 2024; Accepted: 04 Dec 2024.

    Copyright: © 2024 Jiang, Yin, Wang, Yuan, Wu and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yi Lu, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China

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