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REVIEW article

Front. Public Health
Sec. Environmental Health and Exposome
Volume 12 - 2024 | doi: 10.3389/fpubh.2024.1466967
This article is part of the Research Topic Lifestyle and Environmental Factors and Human Fertility View all articles

Endocrine disruptor chemicals exposure and female fertility declining: from pathophysiology to epigenetic risks

Provisionally accepted
Sophian Tricotteaux-Zarqaoui Sophian Tricotteaux-Zarqaoui 1,2Marwa Lahimer Marwa Lahimer 1,2,3Maria Abou Diwan Maria Abou Diwan 1,2,4Aurélie Corona Aurélie Corona 1,2Pietra Candela Pietra Candela 4Rosalie Cabry Rosalie Cabry 1,2,3Véronique Bach Véronique Bach 1,2Hafida Khorsi-Cauet Hafida Khorsi-Cauet 1,2,4*Moncef Benkhalifa Moncef Benkhalifa 1,2,3
  • 1 Périnatalité & Risques Toxiques, Salouël, France
  • 2 PERITOX - Périnatalité et Risques Toxiques – UMR_I 01, Centre Universitaire de Recherche en Santé, CURS-UPJV, University of Picardy Jules Verne, CEDEX 1, 80054 Amiens, France., Amiens, Picardy, France
  • 3 ART and Reproductive Biology Laboratory, University Hospital and School of Medicine, CHU Sud, Amiens, France
  • 4 Laboratoire de la barrière hémato-encéphalique, Université d'Artois, Lens, France

The final, formatted version of the article will be published soon.

    Over the last decades, human infertility has become a major concern in public health, with severe societal and health consequences. Growing evidence shows that endocrine disruptors chemicals (EDCs) have been considered as risk factors of infertility. Their presence in our everyday life has become ubiquitous because of their universal use in food and beverage containers, personal care products, cosmetics, phytosanitary products. Exposure to these products has an impact on human reproductive health. Recent studies suggest that women are more exposed to EDCs than men due to higher chemical products use. The aim of this review is to understand the possible link between reproductive disorders and EDCs such as phthalates, bisphenol, dioxins, and pesticides. In women, the loss of endocrine balance leads to altered oocyte maturation, competency, anovulation and uterine disorders, endometriosis, premature ovarian insufficiency (POI) or embryonic defect and decreases the in vitro fertilization outcomes. In this review, we consider EDCs effects on the women's reproductive system, embryogenesis, with a focus on associated reproductive pathologies.

    Keywords: endocrine disrupting chemicals, Female fertility, epigenetic, Endometriosis, Pesticides, female reproductive disorder, Infertility

    Received: 18 Jul 2024; Accepted: 19 Nov 2024.

    Copyright: © 2024 Tricotteaux-Zarqaoui, Lahimer, Abou Diwan, Corona, Candela, Cabry, Bach, Khorsi-Cauet and Benkhalifa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hafida Khorsi-Cauet, Périnatalité & Risques Toxiques, Salouël, France

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.