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ORIGINAL RESEARCH article

Front. Public Health
Sec. Environmental Health and Exposome
Volume 12 - 2024 | doi: 10.3389/fpubh.2024.1462548
This article is part of the Research Topic Impact of Environmental Factors on the Health of Children and Older Adults View all articles

Association between long-term exposure to PM2.5 chemical components and metabolic syndrome in middle-aged and older adults

Provisionally accepted
Jingjing Zhang Jingjing Zhang 1*Jinglong Zhang Jinglong Zhang 2Zhizhou Duan Zhizhou Duan 3Jin Nie Jin Nie 4Xiangyu Li Xiangyu Li 5*Wenyuan Yu Wenyuan Yu 6*Zhiping Niu Zhiping Niu 7Yangjin Yan Yangjin Yan 8*
  • 1 Northwest Women’s and Children’s Hospital, Xian, Shaanxi Province, China
  • 2 Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi Province, China
  • 3 Jiangxi Provincial People's Hospital, Nanchang, Jiangxi Province, China
  • 4 Nanjing University of Posts and Telecommunications, Nanjing, Jiangsu Province, China
  • 5 Shanghai Tenth People's Hospital, Tongji University, Shanghai, Shanghai Municipality, China
  • 6 Wuhan University, Wuhan, Hubei Province, China
  • 7 School of Public Health, Fudan University, Shanghai, China
  • 8 Xi’an Third Hospital, Northwest University, Xi 'an, China

The final, formatted version of the article will be published soon.

    Background: Previous studies indicated that exposure to ambient fine particulate matter (PM2.5) could increase the risk of metabolic syndrome (MetS). However, the specific impact of PM2.5 chemical components remains uncertain. Methods: A national cross-sectional study of 12,846 Chinese middle-aged and older adults was conducted. Satellite-based spatiotemporal models were employed to determine the 3-year average PM2.5 components exposure, including sulfates (SO42-), nitrates (NO3–), ammonia (NH4+), black carbon (BC), and organic matter (OM). Generalized linear models were used to investigate the associations of PM2.5 components with MetS and the components of MetS, and restricted cubic splines curves were used to establish the exposure-response relationships between PM2.5 components with MetS, as well as the components of MetS. Results: MetS risk increased by 35.1%, 33.5%, 33.6%, 31.2%, 32.4%, and 31.4% for every inter-quartile range rise in PM2.5, SO42-, NO3-, NH4+, OM and BC, respectively. For MetS components, PM2.5 chemical components were associated with evaluated risks of central obesity, high blood pressure (high-BP), high fasting glucose (high-FBG), and low high-density lipoprotein cholesterol (low-HDL). Conclusion: This study indicated that exposure to PM2.5 components is related to increased risk of MetS and its components, including central obesity, high-BP, high-FBG, and low-HDL. Moreover, we found that the adverse effect of PM2.5 chemical components on MetS was more sensitive to people who were single, divorced, or widowed than married people.

    Keywords: Air Pollution, Particulate Matter, metabolic dysfunction, Middle-aged and older adults, Marital Status

    Received: 10 Jul 2024; Accepted: 08 Aug 2024.

    Copyright: © 2024 Zhang, Zhang, Duan, Nie, Li, Yu, Niu and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jingjing Zhang, Northwest Women’s and Children’s Hospital, Xian, 710061, Shaanxi Province, China
    Xiangyu Li, Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200070, Shanghai Municipality, China
    Wenyuan Yu, Wuhan University, Wuhan, 430072, Hubei Province, China
    Yangjin Yan, Xi’an Third Hospital, Northwest University, Xi 'an, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.