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ORIGINAL RESEARCH article

Front. Public Health
Sec. Infectious Diseases: Epidemiology and Prevention
Volume 12 - 2024 | doi: 10.3389/fpubh.2024.1459712

Lactate dehydrogenase to albumin ratio(LAR)is a novel predictor of fatal outcome in patients with SFTS : an observational study

Provisionally accepted
Tao Meng Tao Meng 1Wenqian Ding Wenqian Ding 1Dongmei Lv Dongmei Lv 1Cheng-Xu Wang Cheng-Xu Wang 2Yuanhong XU Yuanhong XU 1*
  • 1 First Affiliated Hospital of Anhui Medical University, Hefei, China
  • 2 Anhui Medical University, Hefei, Anhui Province, China

The final, formatted version of the article will be published soon.

    Background: Severe fever with thrombocytopenia syndrome (SFTS) is a serious infectious disease. This study explored the prognostic value of lactate dehydrogenase (LDH) to albumin (ALB) ratio (LAR) levels in fatal outcomes of the disease. Methods: Two-hundred and nine patients with SFTS were enrolled in this study.Based on the prognosis, patients were divided into survival and deceased groups. Laboratory metrics were compared by univariate Cox regression and multivariate Cox regression analyses. The prognostic risk factors for SFTS disease were discussed, and the receiver operator characteristic (ROC) curve and the Kaplan-Meier survival curve were plotted to analyze the predictive value of independent risk factors on disease prognosis. Results: A total of 209 patients with SFTS, including 152 in the survival group and 57 in the death group, were enrolled. The median age of 209 SFTS patients was 64 years.Three indicators, age, aspartate aminotransferase (AST), and LAR, were identified as predictors of mortality in patients with SFTS. The area under the ROC curve of LAR was the highest (0.835), followed by that of AST (0.794), and age (0.720). The Kaplan-Meier survival curve showed an increased case fatality rate, of >1.4691, in patients with LAR.Conclusion: Elevated LAR level on admission is an independent risk factor for fatal outcomes in patients with SFTS; this can help healthcare professionals identify patients with SFTS having a high risk of fatal outcomes.

    Keywords: albumin, Lactate dehydrogenase, Severe fever and thrombocytopenia syndrome, LAR, predictor

    Received: 04 Jul 2024; Accepted: 30 Nov 2024.

    Copyright: © 2024 Meng, Ding, Lv, Wang and XU. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yuanhong XU, First Affiliated Hospital of Anhui Medical University, Hefei, China

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