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CLINICAL TRIAL article
Front. Public Health
Sec. Public Health Education and Promotion
Volume 12 - 2024 |
doi: 10.3389/fpubh.2024.1451101
This article is part of the Research Topic Exploring the Interaction between Health-promoting and Health Risk Behaviors in Health, Volume II View all 9 articles
Improving Physical and Mental Health in Women with Breast Cancer Undergoing Anthracycline-Based Chemotherapy Through Wearable Device-Based Aerobic Exercise: A Randomized Controlled Trial
Provisionally accepted- 1 South-Central Minzu University, Wuhan, Hebei Province, China
- 2 Beijing Sport University, Beijing, Beijing Municipality, China
- 3 Sanhuan Cancer Hospital, Beijing, China
- 4 The University of Sydney, Darlington, New South Wales, Australia
- 5 National Cancer Center, Chinese Academy of Medical Sciences, Beijing, China
Purpose: Aimed to assess the impact of wearable device-based aerobic exercise on the physical and mental well-being of women with breast cancer (BC) undergoing chemotherapy.Methods: Forty adult women with BC who underwent anthracycline-based chemotherapy were randomly allocated to the exercise group (n=21) or the control group (n=19). Both groups received standard health education and oncology care. In addition, the exercise group wore wearable devices to engage in moderate to highintensity (50%-90% HRmax) aerobic exercise during chemotherapy, while the control group did not carry out exercise intervention. Health-related physical fitness level, physical activity energy expenditure (PAEE), anxiety and depression scores, sleep quality, cancer-related fatigue, and overall quality of life (QoL), were assessed both before (prior to the first chemotherapy session) and after (prior to the fifth chemotherapy session) the exercise intervention. Exercise-related adverse events, exercise compliance, number and severity of gastrointestinal reactions and myelosuppression occurred were recorded during the exercise intervention.Results: After the intervention, compared to the control group, the exercise group (1) had significantly higher relative VO2peak (P=0.003) and handgrip strength (P<0.001);(2) had significantly higher PAEE (P<0.001); (3) had a significantly lower scores in anxiety (P=0.007), depression (P=0.028), sleep quality in domains of subjective sleep quality (P=0.010), sleep disturbances (P=0.004), daytime dysfunction (P=0.007), cancer-related fatigue in domains of physical (P<0.001) and affective (P<0.001); and(4) had a significantly lower scores in QoL in domains of physical well-being (P<0.001) and emotional well-being (P=0.019), while a significantly higher scores in functional well-being (P<0.001). Patients in the exercise group experienced less severe gastrointestinal reactions (P=0.028) and myelosuppressive symptoms (P<0.001) than that in the control group. Patients in the exercise group had no serious exercise-related adverse events, with a mean exercise adherence of 81.8%.Wearable device-based aerobic exercise during chemotherapy can be an effective adjunctive therapy to improve physical and mental health in BC patients.Trial registration: This trial was registered on Chinese Clinical Trial Registry (ChiCTR2300073667).
Keywords: Wearable Device, aerobic exercise, breast cancer, Physical Fitness, Mental Health
Received: 18 Jun 2024; Accepted: 03 Sep 2024.
Copyright: © 2024 Li, Sang, Gong, Wang, Wang, Jia, Yu, Kong, Liu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Boliang Wang, The University of Sydney, Darlington, NSW 2006, New South Wales, Australia
Jingjing Yu, Beijing Sport University, Beijing, 100084, Beijing Municipality, China
Zhenxing Kong, Beijing Sport University, Beijing, 100084, Beijing Municipality, China
Haiyun Liu, Beijing Sport University, Beijing, 100084, Beijing Municipality, China
Yimin Zhang, Beijing Sport University, Beijing, 100084, Beijing Municipality, China
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