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ORIGINAL RESEARCH article

Front. Public Health
Sec. Infectious Diseases: Epidemiology and Prevention
Volume 12 - 2024 | doi: 10.3389/fpubh.2024.1440480

Epidemiology and genotypes analysis of human papillomavirus infection in Huizhou, China

Provisionally accepted
Shu Zhun Shu Zhun 1Wenli Zhao Wenli Zhao 1Xuebing Zhan Xuebing Zhan 1Jiaqi Zeng Jiaqi Zeng 2*Jingyi Li Jingyi Li 3*
  • 1 Department of Pathology, Huizhou First Hospital, Huizhou, Guangdong Province, China
  • 2 Department of Dermatology, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, China
  • 3 Department of Dermatology, Huizhou First Hospital, Huizhou, China

The final, formatted version of the article will be published soon.

    Background: Human papillomavirus (HPV) is a main pathogenic factor for cervical carcinoma. The prevalence and genotypes distribution of HPV vary in different regions. Thus, our study aimed to investigate the epidemiology of HPV in Huizhou, China. Methods: HPV tests were detected in 5,325 female outpatients, we focused on the overall HPV prevalence, genotypes distribution, and the correlation of HPV genotypes with cervical cytology. Results: The overall HPV prevalence was 27.53%, HPV52, HPV58, HPV39, HPV16 and HPV51 were predominant genotypes with single infection rate of 70.80%. HPV infection rate showed a U-shaped age distribution, statistical differences were observed among 5 age groups (χ2 =50.497，P＜0.01), and the higher positive rate was aged under 30 (34.42%) and above 60 (34.74%). Among high-risk HPV (hrHPV) infections, 60.69% involved NILM, 0.99% HSIL. The degrees of cervical lesions in multiple hrHPV infections were worse than those in single infection (P<0.01). Conclusion: The HPV infection rate is high in Huizhou, Guangdong, single infection was predominant. HPV infection presented with a U-shaped age distribution. Multiple hrHPV infection was worrying since it may aggravate cervical lesions. Women should pay more attention to HPV detection and choose a more appropriate HPV vaccine according to local HPV type distribution.

    Keywords: Human papillomavirus (HPV), cervical cancer, cervical lesions, Genotype, Infection, China

    Received: 29 May 2024; Accepted: 31 Jul 2024.

    Copyright: © 2024 Zhun, Zhao, Zhan, Zeng and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jiaqi Zeng, Department of Dermatology, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, China
    Jingyi Li, Department of Dermatology, Huizhou First Hospital, Huizhou, China

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