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ORIGINAL RESEARCH article

Front. Public Health
Sec. Aging and Public Health
Volume 12 - 2024 | doi: 10.3389/fpubh.2024.1435004
This article is part of the Research Topic Methods in Stroke Research: Towards a Better Understanding of Stroke in the Very Old View all articles

Combined Impact of Elevated C-Reactive Protein Levels and Dyslipidemia on Stroke: A CHNS Prospective Cohort Study

Provisionally accepted
Meiru Lv Meiru Lv 1Chang Su Chang Su 1,2Feifei Huang Feifei Huang 1Xiaofang Jia Xiaofang Jia 1Jiguo Zhang Jiguo Zhang 1,2Huijun Wang Huijun Wang 1,2Xiaoyu Wu Xiaoyu Wu 1Weiwei Zhou Weiwei Zhou 1Wenwen Du Wenwen Du 1*
  • 1 National Institute for Nutrition and Health, Chinese Center For Disease Control and Prevention, Beijing, China
  • 2 Key Laboratory of Trace Element Nutrition, National Health Commission, Beijing, Beijing, China

The final, formatted version of the article will be published soon.

    The objective of this study was to examine whether the combination of elevated levels of C-reactive protein (CRP) and dyslipidemia increased the risk of stroke among middle-aged and elderly individuals in China.This study utilized longitudinal data from the China Health and Nutrition Survey (CHNS) collected in 2009, 2015, and 2018. A total of 8,023 participants aged ≥40 years (3,595 males and 4,428 females) were included. The Generalized Estimating Equation (GEE) method was employed to examine the association between inflammation, dyslipidemia, their combined effects, and stroke in the Chinese population.Results: A total of 174 stroke events occurred during follow-up. Compared with those with normal CRP levels (CRP≤3mg/L) , the adjusted ORs and 95%CI were 2.13 (1.25, 3.64) for the female with elevated CRP level. Compared with those with non-dyslipidemia, the adjusted ORs and 95%CI were 1.56 (1.03, 2.37) for the individuals with high LDL cholesterol, 1.93 (1.12, 3.33) for the male with high LDL cholesterol. Compared with those with normal CRP levels and non-dyslipidemia, the adjusted ORs and 95%CI were 1.74 (1.08, 2.78) for the individuals with elevated CRP levels and dyslipidemia, 2.41 (1.29, 4.49) for the male with elevated CRP levels and dyslipidemia. People with the coexistence of elevated CRP levels and dyslipidemia had the highest risk of stroke among male.In females, higher levels of inflammation are associated with an increased incidence of stroke. In males, individuals with dyslipidemia characterized by high LDL cholesterol levels are more susceptible to stroke. In the general population, the joint effect of inflammation and dyslipidemia predisposes individuals to a higher risk of stroke, particularly among males.

    Keywords: C-Reactive Protein, Dyslipidemia, Stroke, Interaction, Health

    Received: 20 May 2024; Accepted: 05 Aug 2024.

    Copyright: © 2024 Lv, Su, Huang, Jia, Zhang, Wang, Wu, Zhou and Du. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Wenwen Du, National Institute for Nutrition and Health, Chinese Center For Disease Control and Prevention, Beijing, China

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