Skip to main content

ORIGINAL RESEARCH article

Front. Public Health
Sec. Aging and Public Health
Volume 12 - 2024 | doi: 10.3389/fpubh.2024.1432742
This article is part of the Research Topic Screening Remnant Lipid Markers in Cardiometabolic Diseases View all articles

Combined effect of triglyceride glucose-body mass index and hypertension on new-onset stroke: evidence from the China Health and Retirement Longitudinal Study (CHARLS)

Provisionally accepted
Fucun Ma Fucun Ma 1,2Jiaying Hu Jiaying Hu 2*Zheng Gao Zheng Gao 2*Xuekai Liu Xuekai Liu 2Mingjian Bai Mingjian Bai 2*Guowei Liang Guowei Liang 2*
  • 1 Other, Beijing, China
  • 2 Department of Clinical Laboratory, Aerospace Center Hospital, Beijing, China

The final, formatted version of the article will be published soon.

    The aim of this study is to investigate the combined impact of the triglyceride glucose-body mass index (TyG-BMI) and hypertension on the risk of stroke among the middle-aged and elderly population in China.Methods: This study included 6,922 participants aged 45 and above from the China Health and Retirement Longitudinal Study, utilizing a multivariate Cox proportional hazards regression model to explore the relationship between TyG-BMI, hypertension, and the incidence of new-onset stroke events, as well as conducting Net Reclassification Improvement (NRI) and Integrated Discrimination Improvement (IDI) analyses to evaluate the predictive utility of TyG-BMI.Results: During a 7-year follow-up period, a total of 401 stroke events were recorded.Compared to patients with lower TyG-BMI (TyG-BMI < 199.74) levels and nonhypertension, those with elevated TyG-BMI levels and non-hypertension had an adjusted hazard ratio (HR) and 95% confidence intervals (95%CI) were 1.47 (1.05 -2.05). The adjusted HR and 95%CI for the group with lower TyG-BMI levels and hypertension was 2.99 (2.17 -4.12), and for those with elevated TyG-BMI levels and hypertension, the adjusted HR and 95%CI was 3.49 (2.63 -4.62). In a multivariate Cox proportional hazards regression model, the combination of elevated TyG-BMI levels and hypertension, treated as routine variables, was still significantly associated with the risk of stroke. NRI and IDI analyses showed significant improvements in risk prediction with the inclusion of TyG-BMI. Furthermore, in all subgroup analyses conducted, individuals with elevated TyG-BMI levels and hypertension nearly exhibited the highest risk for incident stroke.Our study reveals that the combined effect of TyG-BMI and hypertension may increase the risk of incident stroke in the middle-aged and elderly Chinese population. TyG-BMI correlates with comorbid conditions and enhances traditional risk assessment. Future research will require validation through larger sample sizes or diverse populations to further confirm this finding.

    Keywords: Triglyceride glucose-body mass index, Hypertension, Stroke, China health, combined

    Received: 14 May 2024; Accepted: 11 Oct 2024.

    Copyright: © 2024 Ma, Hu, Gao, Liu, Bai and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jiaying Hu, Department of Clinical Laboratory, Aerospace Center Hospital, Beijing, China
    Zheng Gao, Department of Clinical Laboratory, Aerospace Center Hospital, Beijing, China
    Mingjian Bai, Department of Clinical Laboratory, Aerospace Center Hospital, Beijing, China
    Guowei Liang, Department of Clinical Laboratory, Aerospace Center Hospital, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.