AUTHOR=Zong Shuli , Wang Lin , Wang Sutong , Wang Yongcheng , Jiang Yuehua , Sun Liping , Zong Yingying , Li Xiao TITLE=Exposure to per- and polyfluoroalkyl substances is associated with impaired cardiovascular health: a cross-sectional study JOURNAL=Frontiers in Public Health VOLUME=Volume 12 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1418134 DOI=10.3389/fpubh.2024.1418134 ISSN=2296-2565 ABSTRACT=Background: Per-and polyfluoroalkyl substance (PFAS) exposure and cardiovascular disease are controversial. We aimed to assess the association between serum PFAS exposure and cardiovascular health (CVH) in U.S. adults.We analysed serum PFAS concentration data of U.S. adults reported in the National Health and Nutrition Examination Survey (NHANES) study (2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018). We employed two weighted logistic regression models and a restricted cubic spline (RCS) to examine the association between each PFAS and impaired CVH (defined as moderate and low CVH). Quantile g-computation (Qgcomp) and weighted quantile sum (WQS) analysis were used to estimate the effects of mixed exposures to PFASs on impaired CVH.