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ORIGINAL RESEARCH article

Front. Public Health
Sec. Environmental health and Exposome
Volume 12 - 2024 | doi: 10.3389/fpubh.2024.1410406
This article is part of the Research Topic Environmental Risk Factors in Noncommunicable Diseases: New Insights into the Molecular Mechanisms View all articles

The Effects of Ambient Particulate Matter Air Pollution on Platelets and Hemostasis

Provisionally accepted
Sasinee Hantrakool Sasinee Hantrakool 1Maitree Sriwichai Maitree Sriwichai 1Banphot Shaengkhamnang Banphot Shaengkhamnang 1Nipapan Leetrakool Nipapan Leetrakool 1Piangrawee Niprapan Piangrawee Niprapan 1Sawaeng Kawichai Sawaeng Kawichai 2Sitapak Wannakul Sitapak Wannakul 1Noppamas Panyasit Noppamas Panyasit 1Pakinee Tuntivate Pakinee Tuntivate 1Ornkamon Wongtagan Ornkamon Wongtagan 1Rungrote Natesirinilkul Rungrote Natesirinilkul 1Pimpisid Koonyosying Pimpisid Koonyosying 1Phichayut Phinyo Phichayut Phinyo 1Teerachat Punnachet Teerachat Punnachet 1Nonthakorn Hantrakun Nonthakorn Hantrakun 1*Pokpong Piriyakhuntorn Pokpong Piriyakhuntorn 1Thanawat Rattanathammethee Thanawat Rattanathammethee 1Chatree Chai-Adisaksopha Chatree Chai-Adisaksopha 1Ekarat Rattarittamrong Ekarat Rattarittamrong 1Adisak Tantiworawit Adisak Tantiworawit 1Lalita Norasetthada Lalita Norasetthada 1Somdet Srichairatanakool Somdet Srichairatanakool 1
  • 1 Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
  • 2 Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand

The final, formatted version of the article will be published soon.

    Introduction: Elevated ambient pollution exposure is potentially linked to thromboembolism. However, the mechanisms by which particulate matter (PM) interferes with the balance of hemostatic system remain unclear. This study investigates PM-mediated hemostatic changes in individuals across unique seasonal variations of ambient pollution.Methods: This prospective study was conducted between February and July 2020 during alterations in ambient pollution in Chiang Mai, Thailand. Blood tests from 30 healthy subjects were assessed at four-week intervals, four times in total. Various coagulation tests, including prothrombin time (PT), activated partial thromboplastin time (aPTT), von Willebrand factor (vWF), platelet count, and platelet functions, were evaluated. A mixed-effects model was used to analyze the impact of high PM2.5 and PM10 on hemostatic parameters.Results: Thirty male subjects with mean age of 38.9 ± 8.2 years, were included. High levels of PM2.5 and PM10 were significantly associated with PT shortening, with no such effect observed in aPTT. PM2.5 and PM10 values also positively correlated with vWF function, while vWF antigen levels remained unchanged. Soluble P-selectin showed a strong positive association with PM2.5 and PM10 levels. Platelet function analysis revealed no correlation with PM values.Short-term exposure to elevated PM2.5 and PM10 concentrations was linked to shortened PT and enhanced vWF function in healthy individuals. Exploring the impact of these changes on clinically relevant thrombosis is crucial. Additional studies on the pathogenesis of pollution-related thrombosis are warranted for maintaining good health.

    Keywords: Particulate Matter, coagulation, Hemostasis, von Willebrand Factor, Platelet function

    Received: 01 Apr 2024; Accepted: 08 Jul 2024.

    Copyright: © 2024 Hantrakool, Sriwichai, Shaengkhamnang, Leetrakool, Niprapan, Kawichai, Wannakul, Panyasit, Tuntivate, Wongtagan, Natesirinilkul, Koonyosying, Phinyo, Punnachet, Hantrakun, Piriyakhuntorn, Rattanathammethee, Chai-Adisaksopha, Rattarittamrong, Tantiworawit, Norasetthada and Srichairatanakool. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Nonthakorn Hantrakun, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand

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