AUTHOR=Chen Jiping , Lu Yanyu , Yao JiaWei , Zhang Xianliang , Pan Yang 

TITLE=The relationship between accelerometer-based physical activity, sedentary behavior, and seven common geriatric syndromes: a two-sample Mendelian randomization study

JOURNAL=Frontiers in Public Health

VOLUME=12

YEAR=2024

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1406303

DOI=10.3389/fpubh.2024.1406303

ISSN=2296-2565

ABSTRACT=<sec id="sec1"><title>Introduction</title><p>To investigate the causal associations between accelerometer-based physical activity (PA), sedentary behavior (SB), and seven common geriatric syndromes (GSs) (frailty, falls, delirium, urinary incontinence, dysphagia, hearing loss, and visual impairment) by Mendelian randomization (MR) analysis.</p></sec><sec id="sec2"><title>Methods</title><p>Instrumental variables from a genome-wide association study were used for MR analysis. The exposure factors were three PA phenotypes (average acceleration, overall activity, and moderate-intensity activity) and one SB phenotype (SB). The outcome variables were seven common GSs. The inverse variance weighted (IVW) method was utilized for the primary MR analysis. Additionally, sensitivity, pleiotropy, and heterogeneity analyses were subsequently conducted to assess the robustness of the present study’s findings.</p></sec><sec id="sec3"><title>Results</title><p>According to the primary MR results obtained using the IVW method, genetically predicted PA (average acceleration) decreased the risk of two GSs (frailty, <italic>p</italic> = 0.01; dysphagia, <italic>p</italic> = 0.03). Similarly, overall activity decreased the risk of two GSs (frailty, <italic>p</italic> = 0.01; delirium, <italic>p</italic> = 0.03), and moderate-intensity activity reduced the risk of three GSs (urinary incontinence, <italic>p</italic> = 0.04; hearing loss, <italic>p</italic> = 0.02; visual impairment, <italic>p</italic> = 0.01). Furthermore, SB was causally correlated with a greater risk for three GSs (frailty, <italic>p</italic> = 0.03; fall, <italic>p</italic> = 0.01; dysphagia, <italic>p</italic> = 0.04).</p></sec><sec id="sec4"><title>Conclusion</title><p>This study provided evidence that accelerometer-based PA may be causally associated with a lower risk of GSs, while SB may increase the risk of GSs.</p></sec>