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ORIGINAL RESEARCH article

Front. Public Health
Sec. Aging and Public Health
Volume 12 - 2024 | doi: 10.3389/fpubh.2024.1406303
This article is part of the Research Topic Metabolic Diseases and Healthy Aging: Prevention and Public Health Policy Based on Risk Factors View all 8 articles

The relationship between accelerometer-based physical activity, sedentary behaviour and seven common geriatric syndromes: A two-sample Mendelian randomization study

Provisionally accepted
Yanyu Lu Yanyu Lu 1Jiping Chen Jiping Chen 1Jiawei Yao Jiawei Yao 2Xianliang Zhang Xianliang Zhang 1Yang Pan Yang Pan 1*
  • 1 School of Physical Education, Shandong University, Jinan, China
  • 2 Physical Education Teaching and Research Department , Guangdong Dance and Drama College, Foshan, China

The final, formatted version of the article will be published soon.

    To investigate the causal associations between accelerometer-based physical activity (PA), sedentary behavior (SB), and seven common geriatric syndromes (GSs) (frailty, falls, delirium, urinary incontinence, dysphagia, hearing loss, and visual impairment) by Mendelian randomization (MR) analysis. Methods:Instrumental variables from a genome-wide association study were used for MR analysis. The exposure factors were three PA phenotypes (average acceleration, overall activity and moderate-intensity activity) and one SB phenotype (SB). The outcome variables were seven common GSs. The inverse variance weighted (IVW) method was utilized for the primary MR analysis. Additionally, sensitivity, pleiotropy, and heterogeneity analyses were subsequently conducted to assess the robustness of the present study's findings.Results: According to the primary MR results obtained using the IVW method, genetically predicted PA (average acceleration) decreased the risk of two GSs (frailty, P = 0.01; dysphagia, P = 0.03). Similarly, overall activity decreased the risk of two GSs (frailty, P = 0.01; delirium, P = 0.03), and moderate-intensity activity reduced the risk of three GSs (urinary incontinence, P = 0.04; hearing loss, P = 0.02; visual impairment, P = 0.01). Furthermore, SB was causally correlated with a greater risk for three GSs (frailty, p = 2 0.03; fall, p = 0.01; dysphagia, p = 0.04). Conclusions: This study provided evidence that accelerometerbased PA may be causally associated with a lower risk of GSs, while SB may increase the risk of GSs.

    Keywords: Accelerometer-based, physical activity, sedentary behavior, geriatric syndromes, Mendelian randomization

    Received: 24 Mar 2024; Accepted: 19 Jul 2024.

    Copyright: © 2024 Lu, Chen, Yao, Zhang and Pan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yang Pan, School of Physical Education, Shandong University, Jinan, China

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