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ORIGINAL RESEARCH article

Front. Public Health
Sec. Environmental Health and Exposome
Volume 12 - 2024 | doi: 10.3389/fpubh.2024.1389969
This article is part of the Research Topic Effect of Climate Change on Maternal, Perinatal, and Infant Health – From Research to Practice View all articles

Associations between PM2.5, ambient heat exposure and congenital hydronephrosis in southeastern China

Provisionally accepted
Huang Zhi-meng Huang Zhi-meng 1Zhong XiaoHong Zhong XiaoHong 2*Shen Tong Shen Tong 2*Gu SongLei Gu SongLei 2*Chen MengNan Chen MengNan 3*Xu WenLi Xu WenLi 4*Chen RuiQi Chen RuiQi 4*Yang XiaoQing Yang XiaoQing 2*Jinzhun Wu Jinzhun Wu 2*
  • 1 Dept. Pediatrics,, Women and Children's Hospital, School of Medicine, Xiamen University, Xia Men, China
  • 2 Department Pediatrics, Women and Children's Hospital, School of Medicine, Xiamen University, Fujian Province, Xiamen, Fujian Province, China
  • 3 Department Prenatal Diagnosis, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, China
  • 4 Department Pediatrics, Women and Children's Hospital, School of Medicine, Xiamen University, Fujian Provinc, Xiamen, Fujian Province, China

The final, formatted version of the article will be published soon.

    Whether the occurrence of congenital hydronephrosis(CH) is affected by fine particulate matter (PM2.5) and ambient heat exposure during pregnancy.A case-control study was conducted to investigate the relationship between exposure to PM2.5, ambient heat exposure and CH during pregnancy. We included 409 case groups and 409 control groups from 2015 to 2020. By using spatial remote sensing technology to monitor PM2.5 concentration, PM2.5 and ambient temperature exposure were assigned to each participant.The logistics regression model was used to calculate the influence of PM2.5 and ambient heat exposure on CH. Stratified analysis and interaction analysis were used to study the interaction between ambient heat exposure and PM2.5 on the occurrence of CH.At 6 th week of gestation, PM2.5 may increase the risk of CH. For every 10ug/m 3 increase in PM2.5 exposure, the risk of CH increased by 2% (95%CI=0.98,1.05), but P>0.05, indicating that there was no significant relationship between the results. Exposure to intense heat exposure at 6 th and 7 th week of gestation increased the risk of CH. For every 1°C increase in heat exposure, the risk of CH in offspring increased by 21% (95%CI=1.04,1.41) and 13% (95%CI=1.02,1.24), respectively. At 5 th week and 6 th week of gestation, the relative excess risk due to interaction (RERI) was greater than 0 at the 50 th percentile (22.58°C), 75 th percentile (27.25°C), and 90 th percentile (29.13°C) of daily maximum temperature (Tmax) distribution, indicating that the risk of CH was higher than that of single risk factor when exposed to ambient heat exposure and PM2.5 at the same time.Exposure to PM2.5 and ambient heat exposure during pregnancy increases the risk of CH. There was a positive interaction between exposure to intense heat exposure and high concentration of PM2.5 on the occurrence of CH. Keyword： congenital hydronephrosis, heat exposure, PM2.5, China

    Keywords: Congenital hydronephrosis, Heat exposure, PM2.5, China, xia men

    Received: 22 Feb 2024; Accepted: 04 Jul 2024.

    Copyright: © 2024 Zhi-meng, XiaoHong, Tong, SongLei, MengNan, WenLi, RuiQi, XiaoQing and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zhong XiaoHong, Department Pediatrics, Women and Children's Hospital, School of Medicine, Xiamen University, Fujian Province, Xiamen, Fujian Province, China
    Shen Tong, Department Pediatrics, Women and Children's Hospital, School of Medicine, Xiamen University, Fujian Province, Xiamen, Fujian Province, China
    Gu SongLei, Department Pediatrics, Women and Children's Hospital, School of Medicine, Xiamen University, Fujian Province, Xiamen, Fujian Province, China
    Chen MengNan, Department Prenatal Diagnosis, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, China
    Xu WenLi, Department Pediatrics, Women and Children's Hospital, School of Medicine, Xiamen University, Fujian Provinc, Xiamen, Fujian Province, China
    Chen RuiQi, Department Pediatrics, Women and Children's Hospital, School of Medicine, Xiamen University, Fujian Provinc, Xiamen, Fujian Province, China
    Yang XiaoQing, Department Pediatrics, Women and Children's Hospital, School of Medicine, Xiamen University, Fujian Province, Xiamen, Fujian Province, China
    Jinzhun Wu, Department Pediatrics, Women and Children's Hospital, School of Medicine, Xiamen University, Fujian Province, Xiamen, Fujian Province, China

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