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ORIGINAL RESEARCH article
Front. Public Health
Sec. Injury Prevention and Control
Volume 12 - 2024 |
doi: 10.3389/fpubh.2024.1381486
Association of diuretics with falls and wrist fractures: a Mendelian randomization study
Provisionally accepted- Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Background: The association between diuretics and falls in elderly people has been reported in previous studies, but discrepancy remains between the different types of diuretics. The association of diuretics with the risk of wrist fractures due to diuretics is also unclear. Therefore, in this study, we determined the association of diuretics with falls and wrist fractures by Mendelian randomization.Methods: We used a two-sample Mendelian randomization (MR) approach to evaluate the effects of the loop diuretics\potassium-sparing diuretics\thiazide diuretics (LDs\PSDs\TDs) on the risk of falls and wrist fracture using the three diuretic-associated genetically-predicted single nucleotide polymorphisms (SNPs) as genetic tools. The inverse variance weighting (IVW) method was used as the main evaluation method, with odds ratio (OR) as the evaluation criterion. Additionally, weighted median (WME), MR-Egger, weighted mode (WM) and simple mode (SM)methods were used together for the MR analysis, and sensitivity analyses were performed to assess the robustness of the main results.Result: A total of 35 SNPs were included in this study as instrumental variables to replace LDs, PSDs, and TDs, which were 24, 7, and 4. Genetic substitutions for diuretics associated with increased risk of falls were LDs (OR= 1.
Keywords: Diuretics, falls, Wrist fractures, Mendelian randomization, genome-wide association studies
Received: 03 Feb 2024; Accepted: 16 Oct 2024.
Copyright: © 2024 Liu, Dai, Deng, Cao, Cheng and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jun Ze Dai, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Xiao Xi Deng, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Yong Zhong Cheng, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Chao Lu Wang, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
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