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SYSTEMATIC REVIEW article
Front. Public Health
Sec. Public Health Education and Promotion
Volume 12 - 2024 |
doi: 10.3389/fpubh.2024.1373691
Effects of different periodontal interventions on the risk of adverse pregnancy outcomes in pregnant women: a systematic review and network meta-analysis of randomized controlled trials
Provisionally accepted- 1 Shenzhen Institute of Pharmacovigilance and Risk Management, Shenzhen, China
- 2 Southeast University, Nanjing, China
Background: Periodontal disease is widespread among pregnant women, and it is possible that taking action to improve oral health conditions can make improvements in adverse pregnancy outcomes. Herein, we summarize the recent evidence using a network meta-analysis on assessing the effects of different periodontal treatment intervention strategies on the risk of adverse pregnancy outcomes in pregnant women.Material and methods: Randomized controlled trials were retrieved from PubMed, Web of Science, Embase, and Cochrane Library databases. After literature screening, data extraction, and quality evaluation of the included literature are performed, the R studio 4.2.2 'netmeta' package was used for the network meta-analysis.Results: A total of 20 studies were included, and five adverse pregnancy outcomes (preterm birth, low birth weight, preterm birth and/or low birth weight infants, small for gestational age, pre-eclampsia) were considered to examine the effects of different periodontal treatment interventions strategies on the risk of the above outcome indicators. The results of the network meta-analysis demonstrated that the three periodontal treatment intervention strategies of sub-and/or supra-gingival scaling and root planing + chlorhexidine rinsing (SRP+CR), sub-and/or supra-gingival scaling and root planing+chlorhexidine rinsing + tooth polishing and plaque control (SRP+CR+TP), sub-and/or supra-gingival scaling and root planing +sonic toothbrush + tooth polishing and plaque control (SRP+ST+TP) reduced the risk of preterm birth [OR = 0.29, 95CI% (0.10-0.88), OR = 0.25, 95CI% (0.10-0.63), OR = 0.28, 95CI% (0.11-0.69), respectively]. In addition, two periodontal treatment intervention strategies, SRP+CR and SRP+CR+TP, were effective methods in terms of the risk of preterm birth and/or low birth weight [OR = 0.18, 95CI% (0.06-0.52), OR = 0.31, 95CI% (0.12-0.79)].The available evidence suggests that the risk of preterm birth and preterm birth and/or low birth weight can be reduced with certain periodontal treatment intervention strategies. Future studies should focus on optimizing intervention strategies and the optimal timing for different periods of pregnancy, in order to provide a reference for pregnant women's health care.
Keywords: periodontal therapy, intervention measure strategies, Adverse pregnancy outcomes, Network meta-analysis, randomized controlled trials
Received: 20 Jan 2024; Accepted: 03 Sep 2024.
Copyright: © 2024 Wu, Wu, Tang, Zhang, Wei, Yu, Li, Zhao, Wang, Wu and Hong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Biyu Tang, Shenzhen Institute of Pharmacovigilance and Risk Management, Shenzhen, China
Ze Zhang, Southeast University, Nanjing, China
Fenfang Wei, Shenzhen Institute of Pharmacovigilance and Risk Management, Shenzhen, China
Dingbiao Yu, Southeast University, Nanjing, China
Limin Li, Shenzhen Institute of Pharmacovigilance and Risk Management, Shenzhen, China
Yue Zhao, Southeast University, Nanjing, China
Bei Wang, Southeast University, Nanjing, China
Wenyu Wu, Shenzhen Institute of Pharmacovigilance and Risk Management, Shenzhen, China
Xiang Hong, Southeast University, Nanjing, China
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