AUTHOR=Du Yu-Jie , Lu Zhang-Wei , Li Kai-Di , Wang Yi-Yu , Wu Hong , Huang Rong-Gui , Jin Xue , Wang Yi-Yuan , Wang Jing , Geng An-Yi , Li Bao-Zhu 

TITLE=No causal association between pneumoconiosis and three inflammatory immune diseases: a Mendelian randomization study

JOURNAL=Frontiers in Public Health

VOLUME=12

YEAR=2024

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1373044

DOI=10.3389/fpubh.2024.1373044

ISSN=2296-2565

ABSTRACT=<sec id="sec1"><title>Objectives</title><p>To investigate the causal relationships between pneumoconiosis and rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and gout.</p></sec><sec id="sec2"><title>Methods</title><p>The random-effects inverse variance weighted (IVW) approach was utilized to explore the causal effects of the instrumental variables (IVs). Sensitivity analyses using the MR-Egger and weighted median (WM) methods were did to investigate horizontal pleiotropy. A leave-one-out analysis was used to avoid the bias resulting from single-nucleotide polymorphisms (SNPs).</p></sec><sec id="sec3"><title>Results</title><p>There was no causal association between pneumoconiosis and SLE, RA or gout in the European population [OR = 1.01, 95% CI: 0.94–1.10, <italic>p</italic> = 0.74; OR = 1.00, 95% CI: 0.999–1.000, <italic>p</italic> = 0.50; OR = 1.00, 95% CI: 1.000–1.001, <italic>p</italic> = 0.55]. Causal relationships were also not found in pneumoconiosis due to asbestos and other mineral fibers and SLE, RA and gout [OR = 1.01, 95% CI: 0.96–1.07, <italic>p</italic> = 0.66; OR = 1.00, 95% CI: 1.00–1.00, <italic>p</italic> = 0.68; OR = 1.00, 95% CI: 1.00–1.00, <italic>p</italic> = 0.20].</p></sec><sec id="sec4"><title>Conclusion</title><p>Our study suggests that pneumoconiosis may have no causal relationship with the three inflammatory immune diseases.</p></sec>