AUTHOR=Chen Huihui , Ding Xinping , Zhang Wenzhong , Dong Xichen 

TITLE=Coal mining environment causes adverse effects on workers

JOURNAL=Frontiers in Public Health

VOLUME=12

YEAR=2024

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1368557

DOI=10.3389/fpubh.2024.1368557

ISSN=2296-2565

ABSTRACT=<sec id="sec1"><title>Background</title><p>The objective of this study is to study the adverse effects of coal mining environment on workers to discover early effective biomarkers.</p></sec><sec id="sec2"><title>Methods</title><p>The molecular epidemiological study was conducted with 502 in-service workers, who were divided into miner and auxiliary. We measured the individual levels of dust exposure for participants. Clinical examinations were conducted by qualified doctors. Peripheral blood was collected to measure biochemistry, hemogram, and karyocyte apoptosis.</p></sec><sec id="sec3"><title>Results</title><p>All workers were healthy who have not found with any diseases that can be diagnosed medically in the physical examination and showed no difference in dust exposure level, age, height, weight, and body mass index between groups. The working years of miners were lower than that of auxiliaries (<italic>p</italic> &lt; 0.001). Compared with auxiliaries, the concentration and percentage of lymphocytes (<italic>p</italic> = 0.040, <italic>p</italic> = 0.012), basophils (<italic>p</italic> = 0.027, <italic>p</italic> = 0.034), and red blood cells (<italic>p</italic> &lt; 0.001) and the concentration of hemoglobin of miners were lower (<italic>p</italic> &lt; 0.001). The percentage of neutrophils (<italic>p</italic> = 0.003), the concentration of mean corpuscular hemoglobin concentration (<italic>p</italic> = 0.002), and the proportion of karyocyte apoptosis in miners were higher (<italic>p &lt;</italic> 0.001). Miners presented higher blood urea nitrogen (<italic>p</italic> &lt; 0.001), ratio of blood urea nitrogen to creatinine (<italic>p</italic> &lt; 0.001), the high density lipoprotein cholesterol (<italic>p</italic> &lt; 0.001), lower creatinine (<italic>p</italic> &lt; 0.05), and cholesterol (<italic>p</italic> &lt; 0.001).</p></sec><sec id="sec4"><title>Conclusion</title><p>The coal mining environment impacted mining workers’ immune function, renal function, and the hematopoietic system, including BUN/CRE, HGB, RBC, and LYMPH, which could be used as early biomarkers to screen the health of coal miners.</p></sec>