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ORIGINAL RESEARCH article
Front. Public Health
Sec. Infectious Diseases: Epidemiology and Prevention
Volume 12 - 2024 |
doi: 10.3389/fpubh.2024.1354510
Dengue in Pune city, India (2017-2019): A Comprehensive Analysis
Provisionally accepted- 1 Department of Communicable Diseases, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Katraj-Dhankawadi, Pune, Maharashtra, India
- 2 Mankar Children Hospital, Pune, India
- 3 Shivshankar Pote Hospital, Pune,, India
- 4 Independent researcher, Pune, India
- 5 Medicine, Bharati Vidyapeeth Deemed University, Pune, India
- 6 Paediatrics, Bharati Vidyapeeth Deemed University, Pune, Maharashtra, India
Objectives: To understand the dynamics of dengue disease with special reference to (1) age(2) primary/secondary infections (3) serostatus and (4) serotypes examined during three consecutive years. Methods: During 3 dengue seasons (2017-19), NS1/IgM ELISAs were used for dengue diagnosis in one of the 15 administrative wards of Pune City, India. Predefined symptoms were recorded at the time of diagnosis/hospitalization. IgG-capture ELISA (Panbio) was used to differentiate primary/secondary infections. DENV serotypes were determined for 260 viral RNA-positive patients. Results: During the three years, 3014/6786 (44.4%, 41.4-49.9%) suspected cases were diagnosed as dengue. Use of either NS1 or IgM would have missed 25.5% or 43% of the confirmed dengue cases respectively. Notably, a higher proportion of secondary dengue cases remained mild while a substantial proportion of primary infections developed warning signs. The symptoms among Dengue/non-dengue patients and primary/secondary infections varied and influenced by age and serostatus. The number and proportion of dengue serotypes varied yearly. A remarkable decline in dengue cases was observed during the COVID-19 pandemic years. Conclusions: A substantial proportion of primary and secondary dengue patients progress to warning signs/severity or mild infection respectively, underscoring the possible role of non-ADE mechanisms in causing severe dengue that requires hospitalization. Both NS1 and IgM should be used for efficient diagnosis.
Keywords: Dengue, Symptoms, Disease category, Primary dengue, Secondary dengue, India, denv
Received: 12 Dec 2023; Accepted: 10 Sep 2024.
Copyright: © 2024 Arankalle, Shrivastava, Kulkarni, Patil, Tiraki, Mankar, Taru, Lavange, Diwan, Lalwani and Mishra. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Vidya A. Arankalle, Department of Communicable Diseases, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Katraj-Dhankawadi, Pune, Maharashtra, India
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