This article is a commentary on:
The role of single nucleotide polymorphisms related to iron homeostasis in mesothelioma susceptibility after asbestos exposure: a genetic study on autoptic samples
Georgios Tagarakis
Fani Tsolaki2- 1Department of Cardiothoracic Surgery, Aristotle University of Thessaloniki, Thessaloniki, Greece
- 2“Health and Social Care Services Management”, Aristotle University of Thessaloniki, Thessaloniki, Greece
- 3Democritus University of Thrace, Alexandroupolis, Greece
by Grignani, P., Visonà, S. D., Fronda, M. V., Borrelli, P., Monti, M. C., Bertoglio, B., Conti, A., Fattorini, P., and Previderè, C. (2023). Front. Public Health 11:1236558. doi: 10.3389/fpubh.2023.1236558
Introduction
Malignant pleural mesothelioma remains one of the most scientifically interesting and controversial diseases in regard to pathogenesis, prevention and treatment. The role of iron metabolism in the development of this malignancy after asbestos exposure has been supported by various authors. However, recent findings debate the connection between iron and the disease. The scope of this commentary is to express our opinion on the matter taking as a starting point the interesting article by Grignani et al. (1).
Relationship between iron, asbestos and mesothelioma
The recent article by Grignani et al. (1) deals with the role of iron- related genetic polymorphisms after asbestos exposure in the genesis of malignant pleural mesothelioma. Some interesting related issues we would like to comment on are the following:
(i) Malignant pleural mesothelioma remains one of the most controversial and scientifically interesting malignancies as far as pathogenesis, prevention and treatment are concerned. Well-known are, for example, the long debates about the role of extended surgical therapy in form of extrapleural pneumonectomy in comparison with less radical procedures (pleurectomy/decortication) (2) and the role of the still under investigation novel therapies in form of monoclonal antibodies (3).
(ii) The case of asbestos is one of the most classical paradigms relating environmental factors with a disease (4); the asbestos removal campaign has made a great progress, especially in Europe, however must be further expanded toward the target of total eradication (5).
(iii) The role of iron metabolism in the development of mesothelioma has been supported by various authors; it is believed that iron in combination with asbestos exposure induces morbid pathways related to oxidative stress and ferroptosis (6). In this context, the article (1) deals with a hot scientific topic interesting for all scientists fighting the disease. The set-up of the commented study, involving active and control groups and the sufficient sample size, despite some limitations (e.g., the localization of the study) render the results trustworthy and let the debate about the involvement of iron metabolism in the development of malignant pleural mesothelioma pending, awaiting further, larger studies to solve it.
Discussion
Malignant pleural mesothelioma is an aggressive malignancy that has been associated with various controversies in regard to its prevention, diagnosis and treatment (2, 3). Among these controversies one could include the amphibolous role of iron homeostasis after exposure to asbestos in the development of mesothelioma (1, 6). Larger studies, involving more data deriving from a larger sample of patients may elucidate the matter, which could lead to a better preventive or therapeutic approach of malignant pleural mesothelioma.
Author contributions
GT: Conceptualization, Writing – original draft, Writing – review & editing. FT: Investigation, Writing – review & editing. IT: Investigation, Writing – review & editing.
Funding
The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note
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References
1. Grignani P, Visonà SD, Fronda MV, Borrelli P, Monti MC, Bertoglio B, et al. The role of single nucleotide polymorphisms related to iron homeostasis in mesothelioma susceptibility after asbestos exposure: a genetic study on autoptic samples. Front Public Health. (2023) 11:1236558. doi: 10.3389/fpubh.2023.1236558
2. Nakamura A, Kuribayashi K. Do we still need to debate the merits of pleurectomy/decortication vs. extrapleural pneumonectomy for malignant pleural mesothelioma? Transl Lung Cancer Res. (2023) 12:193. doi: 10.21037/tlcr-23-24
3. Assié JB, Jean D. Pleural mesothelioma: a snapshot of emerging drug targets and opportunities for non-surgical therapeutic advancement. Expert Opin Ther Targets. (2023) 30:1–11. doi: 10.1080/14728222.2023.2277224
4. Marinaccio A, Di Marzio D, Mensi C, Consonni D, Gioscia C, Migliore E, et al. Incidence of mesothelioma in young people and causal exposure to asbestos in the Italian national mesothelioma registry (ReNaM). Occup Environ Med. (2023) 80:603–9. doi: 10.1136/oemed-2023-108983
5. Townsend B, Johnson TD, Ralston R, Cullerton K, Martin J, Collin J, et al. framework of NGO inside and outside strategies in the commercial determinants of health: findings from a narrative review. Global Health. (2023) 19:74. doi: 10.1186/s12992-023-00978-x
Keywords: asbestos, mesothelioma, iron metabolism, malignancy, environment
Citation: Tagarakis G, Tsolaki F and Tagarakis I (2024) Commentary: The role of single nucleotide polymorphisms related to iron homeostasis in mesothelioma susceptibility after asbestos exposure: a genetic study on autoptic samples. Front. Public Health 12:1336545. doi: 10.3389/fpubh.2024.1336545
Received: 16 November 2023; Accepted: 02 January 2024;
Published: 16 January 2024.
Edited by:
Giuseppe Broggi, University of Catania, ItalyReviewed by:
Chen Jiang, Hangzhou Normal University, ChinaCopyright © 2024 Tagarakis, Tsolaki and Tagarakis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Georgios Tagarakis, gtagarakis@gmail.com