AUTHOR=Wang Xingzhou , Lin Song , Wang Xiwei , Gao Pengxia , Chen Juan 

TITLE=Association between alcohol consumption and latent fasting blood glucose trajectories among midlife women

JOURNAL=Frontiers in Public Health

VOLUME=12

YEAR=2024

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1331954

DOI=10.3389/fpubh.2024.1331954

ISSN=2296-2565

ABSTRACT=<sec id="sec1"><title>Background</title><p>This investigation sought to elucidate the correlations between alcohol intake and trajectories of fasting blood glucose (FBG) among American women in midlife.</p></sec><sec id="sec2"><title>Methods</title><p>Our analysis was rooted in the foundational data from the Study of Women’s Health Across the Nation (SWAN), a comprehensive longitudinal study centered on US women during their midlife transition. We employed group-based trajectory modeling to chart the FBG trajectories spanning from 1996 to 2005. Employing logistic regression, we gauged the odds ratios (ORs) and 95% confidence intervals (CIs) to draw connections between initial alcohol consumption and FBG trajectory patterns, whilst controlling for predominant potential confounders.</p></sec><sec id="sec3"><title>Results</title><p>Our cohort comprised 2,578 women in midlife, ranging in age from 42 to 52, each having a minimum of three subsequent FPG assessments. We discerned two distinct FBG trajectories: a low-stable pattern (<italic>n</italic> = 2,467) and a high-decreasing pattern (<italic>n</italic> = 111). Contrasted with the low-stable group, our data showcased an inverse relationship between alcohol intake and the high-decreasing FBG trajectory in the fully adjusted model 3. The most pronounced reduction was evident in the highest tertile of daily servings of alcoholic beverages (OR: 0.23, 95% CI: 0.10–0.52, <italic>p</italic> &lt; 0.001), percentage of kilocalories sourced from alcoholic beverages (OR: 0.30, 95% CI: 0.16–0.58, <italic>p</italic> &lt; 0.001), and daily caloric intake from alcoholic beverages (OR: 0.31, 95% CI: 0.16–0.62, <italic>p</italic> &lt; 0.001).</p></sec><sec id="sec4"><title>Conclusion</title><p>Moderate alcohol consumption may protect against high FPG trajectories in middle-aged women in a dose–response manner. Further researches are needed to investigate this causality in midlife women.</p></sec>