AUTHOR=Wu Huiyi , Huang Lei , Zhang Shushan , Zhang Yang , Lan Yajia 

TITLE=Daytime napping, biological aging and cognitive function among middle-aged and older Chinese: insights from the China health and retirement longitudinal study

JOURNAL=Frontiers in Public Health

VOLUME=11

YEAR=2023

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2023.1294948

DOI=10.3389/fpubh.2023.1294948

ISSN=2296-2565

ABSTRACT=<sec id="sec1"><title>Objective</title><p>The complicated association of daytime napping, biological aging and cognitive function remains inconclusive. We aimed to evaluate the cross-sectional and longitudinal associations of daytime napping and two aging measures with cognition and to examine whether napping affects cognition through a more advanced state of aging.</p></sec><sec id="sec2"><title>Methods</title><p>Data was collected from the China Health and Retirement Longitudinal Study. Napping was self-reported. We calculated two published biological aging measures: Klemera and Doubal biological age (KDM-BA) and physiological dysregulation (PD), which derived information from clinical biomarkers. Cognitive z-scores were calculated at each wave. Linear mixed models were used to explore the longitudinal association between napping, two aging measures, and cognitive decline. Mediation analyses were performed to assess the mediating effects of biological age acceleration on the association between napping and cognition.</p></sec><sec id="sec3"><title>Results</title><p>Participants aged over 45 years were included in the analyses. Non-nappers had greater KDM-BA and PD [LS means (LSM) = 0.255, <italic>p</italic> = 0.007; LSM = 0.085, <italic>p</italic> = 0.011] and faster cognitive decline (LSM = −0.061, <italic>p</italic> = 0.005)compared to moderate nappers (30–90 min/nap). KDM-BA (<italic>β</italic> = −0.007, <italic>p</italic> = 0.018) and PD (<italic>β</italic> = −0.034, <italic>p</italic> &lt; 0.001) showed a negative association with overall cognitive z scores. KDM-BA and PD partially mediated the effect of napping on cognition.</p></sec><sec id="sec4"><title>Conclusion</title><p>In middle-aged and older Chinese, compared to moderate nappers, non-nappers seem to experience a more advanced state of aging and increased rates of cognitive decline. The aging status possibly mediates the association between napping and cognition. Moderate napping shows promise in promoting healthy aging and reducing the burden of cognitive decline in Chinese middle-aged and older adults.</p></sec>