AUTHOR=Senok Abiola , Thomsen Jens , Abdulrazzaq Najiba M. ,  The UAE AMR Surveillance Consortium , Menezes Godfred Antony , Ayoub Moubareck Carole , Everett Dean 

TITLE=Antimicrobial resistance in Streptococcus pneumoniae: a retrospective analysis of emerging trends in the United Arab Emirates from 2010 to 2021

JOURNAL=Frontiers in Public Health

VOLUME=11

YEAR=2023

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2023.1244357

DOI=10.3389/fpubh.2023.1244357

ISSN=2296-2565

ABSTRACT=<sec><title>Introduction</title><p>Although pneumococcal conjugate vaccines (PCV) have been effective in reducing the burden of <italic>Streptococcus pneumoniae</italic> infections, there is a paucity of data on the relationship with antimicrobial resistance (AMR) trends in the Arabian Gulf region. This study was carried out to assess <italic>S. pneumoniae</italic> resistance trends in the United Arab Emirates (UAE) where PCV-13 vaccination was introduced in 2011.</p></sec><sec><title>Methods</title><p>Retrospective analysis of <italic>S. pneumoniae</italic> demographic and microbiological data collected as part of the national AMR surveillance program from 2010 to 2021 was carried out. A survey of reporting sites and hand searching of annual reports of local health authorities was carried out to identify data on <italic>S. pneumoniae</italic> serotypes as this is not included in the AMR surveillance database.</p></sec><sec><title>Results</title><p>From 2010 to 2021, 11,242 non-duplicate <italic>S. pneumoniae</italic> isolates were reported, increasing from 324 in 2010 to 1,115 in 2021. Factoring in annual increment in the number of surveillance sites, the number of isolates per site showed an upward trajectory from 2015 to 2018 and declined in 2020 with the onset of the pandemic. The majority of isolates (<italic>n/N</italic> = 5,751/11,242; 51.2%) were from respiratory tract specimens with 44.5% (<italic>n/N</italic> = 2,557/5,751) being nasal colonizers. Up to 11.9% (<italic>n/N</italic> = 1,337/11,242) were invasive pneumococcal disease (IPD) isolates obtained from sterile site specimens including blood (<italic>n</italic> = 1,262), cerebrospinal (<italic>n</italic> = 52), pleural (<italic>n</italic> = 19) and joint (<italic>n</italic> = 4) fluid; and were predominantly from pediatric patients. The downward trend for amoxicillin and for penicillin G at the non-meningitis and meningitis as well as oral penicillin breakpoints was statistically significant. In contrast, increasing trends of resistance were seen for levofloxacin, moxifloxacin, trimethoprim/sulfamethoxazole and erythromycin. IPD and non-IPD isolates showed similar demographic and AMR trends. None of the surveillance sites carried out <italic>S. pneumoniae</italic> serotyping and handsearching of annual reports did not yield this information.</p></sec><sec><title>Conclusion</title><p>The increasing trend of pneumococcal disease and AMR with emergence of isolates with MDR phenotype despite is of concern. In the absence of <italic>S. pneumoniae</italic> serotyping the role of non-vaccine serotypes in driving this pattern remains unknown. There is an urgent need for serotype, genomic and AMR surveillance of <italic>S. pneumoniae</italic> isolates in the UAE.</p></sec>