AUTHOR=Pavan Tycha Bianca Sabaini , Dias Deorlan Pereira , Cangussú Márcia Moraes , Dutra Vilquenia Porto Pacheco , Sampaio Daniel Dias , Santos Fred Luciano Neves 

TITLE=Seroepidemiology of Chagas disease in at-risk individuals in Caraíbas, a city with high endemicity in Bahia State, Brazil

JOURNAL=Frontiers in Public Health

VOLUME=11

YEAR=2023

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2023.1196403

DOI=10.3389/fpubh.2023.1196403

ISSN=2296-2565

ABSTRACT=<sec><title>Introduction</title><p>In Brazil, an estimated 1.1 million people are infected with <italic>Trypanosoma cruzi</italic>, the causative agent of Chagas disease (CD). Despite the high number of cases, the estimated prevalence of infection per 100 inhabitants is low (0.03). However, the actual number of chronically infected individuals is still unknown. Therefore, we sought to determine the prevalence of chronic CD in at-risk individuals in Caraíbas (Bahia, Brazil) through active case finding.</p></sec><sec><title>Methods</title><p>A total of 572 individuals living in rural or urban areas of Caraíbas were eligible for the study. A serum sample was collected from 226 individuals, and the diagnosis performed according to international guidelines.</p></sec><sec><title>Results</title><p>The overall prevalence of anti-<italic>T. cruzi</italic> IgG was 4.42%. The median age of anti-<italic>T. cruzi</italic> IgG-positive individuals was 54.5 years, and the female-to-male ratio was 1.5:1. The prevalence of anti-<italic>T. cruzi</italic> IgG was similar in rural (4.29%) and urban areas (4.65%).</p></sec><sec><title>Discussion</title><p>Compared with national estimates, we concluded that Caraíbas had a high prevalence for chronic CD and a high risk for persistent transmission. Through our study, it was possible to monitor individuals who were unaware of their clinical condition, thus improving their quality of life.</p></sec>