AUTHOR=Wei Huijie , Li Yu , Lei Hua , Ren Junwei 

TITLE=Associations of migraines with suicide ideation or attempts: A meta-analysis

JOURNAL=Frontiers in Public Health

VOLUME=11

YEAR=2023

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2023.1140682

DOI=10.3389/fpubh.2023.1140682

ISSN=2296-2565

ABSTRACT=<sec><title>Objective</title><p>Whether migraine is associated with a higher risk of suicide ideation and/or attempts remains controversial. Therefore, we aimed to evaluate these potential associations in migraine patients by performing a meta-analysis of previously published data.</p></sec><sec><title>Methods</title><p>We searched for studies published up to 31 June 2022 that compared the risk of suicide ideation/attempt in migraineurs and non-migraineurs in PubMed, EMBASE, and Web of Science databases. Sixteen studies fulfilled the eligibility criteria. We applied Random-effects models to calculate pooled adjusted odds ratios (AORs) and 95% confidence intervals (CIs) in patients with migraine.</p></sec><sec><title>Results</title><p>Migraine patients were at a significantly increased risk of suicide ideation (AOR 1.33, 95% CI 1.15–1.54) and suicide attempts (AOR 1.70, 95% CI 1.42–2.03). The increase in risk may be greater in adults (&gt;19 years) than in younger individuals.</p></sec><sec><title>Conclusion</title><p>The available evidence indicates a significant association of migraines with suicide ideation and attempts. Future work should confirm and extend these findings, as well as explore whether they are affected by ethnicity or geography.</p></sec>