AUTHOR=Essery Rosie , Pollet Sebastien , Bradbury Katherine , Western Max J. , Grey Elisabeth , Denison-Day James , Smith Kirsten A. , Hayter Victoria , Kelly Joanne , Somerville Jane , Stuart Beth , Becque Taeko , Zhang Jin , Slodkowska-Barabasz Joanna , Mowbray Fiona , Ferrey Anne , Yao Guiqing , Zhu Shihua , Kendrick Tony , Griffin Simon , Mutrie Nanette , Robinson Sian , Brooker Helen , Griffiths Gareth , Robinson Louise , Rossor Martin , Ballard Clive , Gallacher John , Rathod Shanaya , Gudgin Bernard , Phillips Rosemary , Stokes Tom , Niven John , Little Paul , Yardley Lucy TITLE=Parallel randomized controlled feasibility trials of the “Active Brains” digital intervention to protect cognitive health in adults aged 60–85 JOURNAL=Frontiers in Public Health VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.962873 DOI=10.3389/fpubh.2022.962873 ISSN=2296-2565 ABSTRACT=Introduction

Multidomain interventions to address modifiable risk factors for dementia are promising, but require more cost-effective, scalable delivery. This study investigated the feasibility of the “Active Brains” digital behavior change intervention and its trial procedures.

Materials and methods

Active Brains aims to reduce cognitive decline by promoting physical activity, healthy eating, and online cognitive training. We conducted 12-month parallel-design randomized controlled feasibility trials of “Active Brains” amongst “lower cognitive scoring” (n = 180) and “higher cognitive scoring” (n = 180) adults aged 60–85.

Results

We collected 67.2 and 76.1% of our 12-month primary outcome (Baddeley verbal reasoning task) data for the “lower cognitive score” and “higher cognitive score” groups, respectively. Usage of “Active Brains” indicated overall feasibility and satisfactory engagement with the physical activity intervention content (which did not require sustained online engagement), but engagement with online cognitive training was limited. Uptake of the additional brief telephone support appeared to be higher in the “lower cognitive score” trial. Preliminary descriptive trends in the primary outcome data might indicate a protective effect of Active Brains against cognitive decline, but further investigation in fully-powered trials is required to answer this definitively.

Discussion

Whilst initial uptake and engagement with the online intervention was modest, it was in line with typical usage of other digital behavior change interventions, and early indications from the descriptive analysis of the primary outcome and behavioral data suggest that further exploration of the potential protective benefits of Active Brains are warranted. The study also identified minor modifications to procedures, particularly to improve online primary-outcome completion. Further investigation of Active Brains will now seek to determine its efficacy in protecting cognitive performance amongst adults aged 60–85 with varied levels of existing cognitive performance.