AUTHOR=Srikanth Narayanam , Kumar Adarsh , Chandrasekhararao Bhogavalli , Singhal Richa , Yadav Babita , Khanduri Shruti , Jameela Sophia , Rai Amit Kumar , Tripathi Arunabh , Rana Rakesh , Ahmad Azeem , Sharma Bhagwan Sahai , Jaiswal Ankit , Kotecha Rajesh , State Level Collaborators , Nesari Tanuja , Vyas Mahesh , Tagade Umesh , Thakar Anup , Bhatt Nilesh , Dattani Kalpesh , Bhinde Sagar , Sharma Sanjeev , Godatwar Pawan Kumar , Ojha Nisha , Meena H.M.L. , Bhakuni Harish , Goswami Pradeep Kumar , Choudhury Bishnu , Nishanth K , Sai Prasad AJV , Dhoke Sujata , Midhuna Mohan K , Gopod Savita , Arvind Kumar , Dogra Ekta , Bora G.K. , Pravin K S , Radheshyam Pravin Masarom , Bharati P.L. , Das Jeuti Rani , Tewari Vimal , Tewari Deepika , Mishra Ritika , Kuldeep , Rotwar D.S. , Ahvad Anil , Paikrao Sumed , Madan Amit , Jadhav Nandini , Nariyal Vikas , Vyas Kavita , Chandla Anubha , Negi Vineeta , Antony Chris , Sharma Vipin , Mohod Poonam , Sharma Subhash , Suri Meenakshi , Shah Aaditya , Ramana G.V. , Tejaswini C , Raghavendra , Giri S.K. , Doddamani Shashidhar , Shubhashree M.N , Sahoo Srinibash , Pratap Shankar K.M. , Nair Parvathy.G. , Nair Devi R , Krishna Kumar V. , Pradeep Kumar P.P. , Remya E , Karthika A P , Sinimol T.P , Meghna P P , Balakrishnan Praveen , Surendran Emy.S. , Sumedhan Varsha , Kumar Amit , Singh S.B. , Singh Neelam , Mangal Anil , Sharma Deepa , Bhurke Laxman , Dighe Dattatray , Choudhary Kuldeep , Deshmukh Saylee , Marlewar Sneha , Kale Shyam , Shekhar Namboori U.R. , Sharma Savita , Thakre Priya , Shinde Prashant , Potbare Balaji , Rahangdale Deepak , Magh Gwachung , Bhuyan G.C. , Panda P. , Ratha K.K. , Rao Krishna , Indu S , Panda A.K. , Das Banamali , Ota Susmita , Tomar Rinku , Singh Harbans , Baheti Sandeep , Kumar Sanjeev , Mahesh S , Sangvikar Sangeeta , Vedi S.K. , Sharma Swati , Kumawat V.B. , Choudhary Suhash , Kumari Monika , Indu P P , Ghuse Rahul D. , Shriprakash , Sahu Shrawan Kumar , Sinha Ashok Kumar , Srinivas P. , Prameela Devi K. , Asha S , Niral Sojeetra , Singh Karisma , Pallavi Kamble , Singh Ravi Ranjan , Prasad Anjali B , Surana Mayur , Singh Sanjay Kumar , Kumari Harit , Srivastava A.K. , Kumar Tarun , Arya Deepshikha , Sahu D.S. , Mondal Tushar Kanti , Barik L.D. , Saha Suparna , Ekka Ranjita , Bhushan Shakti , Mitra Achintya , Debnath Saroj Kumar , Das Debajyoti , Akashlal M , Abhayadev A , Gupta Hemant , Yadav Ajay P , Khan Asim Ali , Kazmi Munawar H , Minhaj , Raza Rahat , Khan Md.Nafees , Alam Md. Ishtiyaq , Lari Haseeb Alam , Zaheer Ahmed N. , Khan Hakimuddin , Iftikhar Younis , Akbar Seema , Afza Sheeren , Fazil Mohammad , Kumar Ashok , Tarique Mohd , Khan Amir Faisal , Khan Amir Faisal , Ahmed Aijaz , Khurana Anil , Karunakara Moorthi S. , Kaushik Subhash , Saklani Nitin Kumar , Rawat B. S. , Bezawada Brunda , Ramteke Sunil , Prusty A.K. , Karso Liyi , Srivastav Amit , Shil Ratan Chandra , Pal Partha Pratim , Debata Lipipushpa , Ravi Chandra Reddy G. , Prasad Sunil , Singh Uttam , Bhattacharjee Baidurjya , Tamang Santosh Kumar , Sadarla Ravi kumar , Sharma Pawan , Sahoo Amulya Ratna , Vibha , Prasad P , Karthikeyan D. , Rao Raghvendra , Sandhu Surender , Rao Mohan , Vadiraj HS , Basavaraddi Ishwar V. , Achary Ishwar N , Satyalakshmi K , Shivkesh , Yuvaraj Paul P. , Singh Subhas , Jose Austin , Teron Robindra , Imlikumba , Wadud Addul , Ansari Abdul Nasir , Khan Tariq Nadeem , Moheen Abdul , Dolma Tsewang , Tenba Tenzin , Srivastav Anupam , Ramakrishnan N. , Soni Surendra , Shukla Ram , Salve Rohini , Shaikh M.N. , Trivedi Daxen , Bhagiya Shital , Patel Asha , Indoriya Anup , Gandhi Rachna , Jain Naresh , Chavada Nirmal , Shingadiya Rahul , Bhadraka Nilesh , Gupta Nrupesh , Italiya Dilip , Shah Piyush , Chaudhari Maya , Patel Sumit , Chaudhari Bhavin , Parmar Mehul TITLE=Disease Characteristics, Care-Seeking Behavior, and Outcomes Associated With the Use of AYUSH-64 in COVID-19 Patients in Home Isolation in India: A Community-Based Cross-Sectional Analysis JOURNAL=Frontiers in Public Health VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.904279 DOI=10.3389/fpubh.2022.904279 ISSN=2296-2565 ABSTRACT=Background

During the second wave of the COVID-19 pandemic in India, the Ministry of Ayush conducted a community study to provide therapeutic care to patients with asymptomatic, mild, and moderate COVID-19 in home isolation based on the empirical evidence generated on the efficacy of AYUSH-64 in COVID-19.

Objective

To document disease characteristics, care-seeking behavior, and outcomes in patients with asymptomatic, mild, or moderate COVID-19 in home isolation who used AYUSH-64 for COVID-19.

Methods

Cross-sectional analysis of the data generated through a community study conducted in India from 08 May to 31 August 2021 was performed to study the disease characteristics, care-seeking behavior during home isolation, clinical outcomes, adverse events, and the association between various risk factors and clinical recovery during the study period. The data were collected through semi-structured questionnaires, available in electronic data collection format at the baseline, 7, 14, and 21 days. A logistic regression was performed to explore the relationship between relevant variables and clinical recovery.

Results

Data from 64,642 participants were analyzed for baseline assessment, and final analysis was done for 49,770 participants. The mean age of the enrolled participants was 38.8 ± 11.7 years, and 8.4% had co-morbidities. AYUSH-64 was utilized as an add-on to the standard care by 58.3% of participants. Comparable clinical outcomes were observed in participants utilizing AYUSH-64 either as a standalone or as an add-on to standard care, in terms of clinical recovery, disease progression, the requirement for oxygen supplementation, hospitalization, ICU admission, and need for ventilator support. Younger age, having no co-morbidities or substance abuse, and having been vaccinated were associated with early clinical recovery than those who were older and not vaccinated.

Conclusions

The study findings suggest that AYUSH-64 use, either standalone or as an adjunct to standard care, in asymptomatic, mild, or moderate COVID-19 is associated with good clinical outcomes. Ayush services and interventions can be effectively integrated into the mainstream public health architecture to serve public health goals.