AUTHOR=Xiang Shiting , Dong Jie , Li Xun , Li Chao 

TITLE=Urine Phthalate Levels and Liver Function in US Adolescents: Analyses of NHANES 2007–2016

JOURNAL=Frontiers in Public Health

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.843971

DOI=10.3389/fpubh.2022.843971

ISSN=2296-2565

ABSTRACT=<sec><title>Background</title><p>Phthalates are non-persistent chemicals with endocrine-disrupting abilities widely used in a variety of consumer products. Evidence for the effects of phthalate exposure on liver function in adolescents is lacking.</p></sec><sec><title>Methods</title><p>Data were analyzed from the combined 2007–2016 National Health and Nutrition Examination Survey (NHANES). Ultimately, a total of 1,650 adolescents aged 12–19 years were selected as the samples. Weighted linear regression was used to investigate the effects of urinary phthalate metabolites on liver function indexes.</p></sec><sec><title>Results</title><p>Weighted Linear regression models showed that MCOP was negatively associated with TBIL (β = −0.0435, <italic>P</italic><sub>FDR</sub> = 0.007), ΣDEHP (β = −0.0453, <italic>P</italic><sub>FDR</sub> = 0.003) and MCOP (β = −0.0379, <italic>P</italic><sub>FDR</sub> = 0.006) were negatively correlated with ALB, while MCPP was positively correlated with ALB (β = 0.0339, <italic>P</italic><sub>FDR</sub> = 0.024), and MCOP was negatively correlated with TP (β = −0.0551; <italic>P</italic><sub>FDR</sub> = 0.004).</p></sec><sec><title>Conclusions</title><p>Phthalate metabolites were significantly but weakly associated with changes in liver function indicators among US adolescents. Future work should further examine these relationships.</p></sec>