AUTHOR=Wan Li , Ai Zhuang , Chen Jinbo , Jiang Qian , Chen Hongying , Li Qi , Lu Yaping , Chen Liuqing TITLE=Detection algorithm for pigmented skin disease based on classifier-level and feature-level fusion JOURNAL=Frontiers in Public Health VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.1034772 DOI=10.3389/fpubh.2022.1034772 ISSN=2296-2565 ABSTRACT=

Pigmented skin disease is caused by abnormal melanocyte and melanin production, which can be induced by genetic and environmental factors. It is also common among the various types of skin diseases. The timely and accurate diagnosis of pigmented skin disease is important for reducing mortality. Patients with pigmented dermatosis are generally diagnosed by a dermatologist through dermatoscopy. However, due to the current shortage of experts, this approach cannot meet the needs of the population, so a computer-aided system would help to diagnose skin lesions in remote areas containing insufficient experts. This paper proposes an algorithm based on a fusion network for the detection of pigmented skin disease. First, we preprocess the images in the acquired dataset, and then we perform image flipping and image style transfer to augment the images to alleviate the imbalance between the various categories in the dataset. Finally, two feature-level fusion optimization schemes based on deep features are compared with a classifier-level fusion scheme based on a classification layer to effectively determine the best fusion strategy for satisfying the pigmented skin disease detection requirements. Gradient-weighted Class Activation Mapping (Grad_CAM) and Grad_CAM++ are used for visualization purposes to verify the effectiveness of the proposed fusion network. The results show that compared with those of the traditional detection algorithm for pigmented skin disease, the accuracy and Area Under Curve (AUC) of the method in this paper reach 92.1 and 95.3%, respectively. The evaluation indices are greatly improved, proving the adaptability and accuracy of the proposed method. The proposed method can assist clinicians in screening and diagnosing pigmented skin disease and is suitable for real-world applications.