AUTHOR=Yan Chengxi , Chang Ying , Yu Huan , Xu Jingxu , Huang Chencui , Yang Minglei , Wang Yiqiao , Wang Di , Yu Tian , Wei Shuqin , Li Zhenyu , Gong Feifei , Kou Mingqing , Gou Wenjing , Zhao Qili , Sun Penghui , Jia Xiuqin , Fan Zhaoyang , Xu Jiali , Li Sijie , Yang Qi TITLE=Clinical Factors and Quantitative CT Parameters Associated With ICU Admission in Patients of COVID-19 Pneumonia: A Multicenter Study JOURNAL=Frontiers in Public Health VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2021.648360 DOI=10.3389/fpubh.2021.648360 ISSN=2296-2565 ABSTRACT=

The clinical spectrum of COVID-19 pneumonia is varied. Thus, it is important to identify risk factors at an early stage for predicting deterioration that require transferring the patients to ICU. A retrospective multicenter study was conducted on COVID-19 patients admitted to designated hospitals in China from Jan 17, 2020, to Feb 17, 2020. Clinical presentation, laboratory data, and quantitative CT parameters were also collected. The result showed that increasing risks of ICU admission were associated with age > 60 years (odds ratio [OR], 12.72; 95% confidence interval [CI], 2.42–24.61; P = 0.032), coexisting conditions (OR, 5.55; 95% CI, 1.59–19.38; P = 0.007) and CT derived total opacity percentage (TOP) (OR, 8.0; 95% CI, 1.45–39.29; P = 0.016). In conclusion, older age, coexisting conditions, larger TOP at the time of hospital admission are associated with ICU admission in patients with COVID-19 pneumonia. Early monitoring the progression of the disease and implementing appropriate therapies are warranted.