AUTHOR=Bai Francesca , Tavelli Alessandro , Mulè Giovanni , Falcinella Camilla , Mondatore Debora , Tesoro Daniele , Barbanotti Diletta , Tomasoni Daniele , Castoldi Roberto , Augello Matteo , Allegrini Marina , Tagliaferri Gianmarco , Cona Andrea , Cozzi-Lepri Alessandro , Marchetti Giulia , d'Arminio Monforte Antonella TITLE=A Quantitative Estimate of the Expected Shortening of the Median Isolation Period of Patients With COVID-19 After the Adoption of a Symptom-Based Strategy JOURNAL=Frontiers in Public Health VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2021.639347 DOI=10.3389/fpubh.2021.639347 ISSN=2296-2565 ABSTRACT=

A long period of isolation was observed in patients hospitalized for COVID-19 in Milan over March-September 2020 (45; IQR: 37–54 days). A significantly shorter period would have been observed by the application of May-WHO (22, IQR: 17–30 days, P < 0.001) and October-Italian (26, IQR: 21–34 days, P < 0.001) Guidelines. The adoption of the new symptom-based criteria is likely to lead to a significant reduction in the length of the isolation period with potential social, economic and psychological benefits, particularly in the younger population with mild/moderate disease and no comorbidities. In our opinion, the release from isolation after 21 days from symptoms onset, even without a PCR diagnostic test, in most cases seems the most adequate strategy that could balance precautions to prevent SARS CoV-2 transmission and unnecessary prolonged isolation or overuse of diagnostic testing.