AUTHOR=Nymark Penny , Sachana Magdalini , Leite Sofia Batista , Sund Jukka , Krebs Catharine E. , Sullivan Kristie , Edwards Stephen , Viviani Laura , Willett Catherine , Landesmann Brigitte , Wittwehr Clemens TITLE=Systematic Organization of COVID-19 Data Supported by the Adverse Outcome Pathway Framework JOURNAL=Frontiers in Public Health VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2021.638605 DOI=10.3389/fpubh.2021.638605 ISSN=2296-2565 ABSTRACT=

Adverse Outcome Pathways (AOP) provide structured frameworks for the systematic organization of research data and knowledge. The AOP framework follows a set of key principles that allow for broad application across diverse disciplines related to human health, including toxicology, pharmacology, virology and medical research. The COVID-19 pandemic engages a great number of scientists world-wide and data is increasing with exponential speed. Diligent data management strategies are employed but approaches for systematically organizing the data-derived information and knowledge are lacking. We believe AOPs can play an important role in improving interpretation and efficient application of scientific understanding of COVID-19. Here, we outline a newly initiated effort, the CIAO project (https://www.ciao-covid.net/), to streamline collaboration between scientists across the world toward development of AOPs for COVID-19, and describe the overarching aims of the effort, as well as the expected outcomes and research support that they will provide.