AUTHOR=Morita Akinori , Wang Bing , Tanaka Kaoru , Katsube Takanori , Murakami Masahiro , Shimokawa Takashi , Nishiyama Yuichi , Ochi Shintaro , Satoh Hidetoshi , Nenoi Mitsuru , Aoki Shin TITLE=Protective Effects of p53 Regulatory Agents Against High-LET Radiation-Induced Injury in Mice JOURNAL=Frontiers in Public Health VOLUME=8 YEAR=2020 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2020.601124 DOI=10.3389/fpubh.2020.601124 ISSN=2296-2565 ABSTRACT=
Radiation damage to normal tissues is one of the most serious concerns in radiation therapy, and the tolerance dose of the normal tissues limits the therapeutic dose to the patients. p53 is well known as a transcription factor closely associated with radiation-induced cell death. We recently demonstrated the protective effects of several p53 regulatory agents against low-LET X- or γ-ray-induced damage. Although it was reported that high-LET heavy ion radiation (>85 keV/μm) could cause p53-independent cell death in some cancer cell lines, whether there is any radioprotective effect of the p53 regulatory agents against the high-LET radiation injury