AUTHOR=Wang Guannan , Xu Zhiwei , Zhu Jie , Ren Jiayu , Chen Mina , He Guijuan , Yu Beibei 

TITLE=Decreased Risk in the Pancreatic Cancer With History of Hay Fever: A Meta-Analysis

JOURNAL=Frontiers in Public Health

VOLUME=8

YEAR=2020

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2020.551490

DOI=10.3389/fpubh.2020.551490

ISSN=2296-2565

ABSTRACT=<p><bold>Background:</bold> An increasing incidence of pancreatic cancer has been observed worldwide over the last few decades. Previous reports suggested that hay fever, a common allergic disease, may function in pancreatic cancer. Data on hay fever as a risk or protective factor for pancreatic cancer was controversial in several case–control reports. So, we here did a meta-analysis on published studies to evaluate the association of hay fever and the risk of pancreatic cancer.</p><p><bold>Methods:</bold> A comprehensive literature search was performed through public databases. The association between hay fever and pancreatic cancer was evaluated by odds ratios (ORs) and 95% confidence intervals (CIs). The Cochran's Q test and I<sup>2</sup> index were used to evaluate heterogeneity.</p><p><bold>Results:</bold> We included 8 population-based case–control studies involving 10,454 participants from 1986 to 2014. A history of hay fever was associated with a decreased risk of pancreatic cancer (OR, 0.57; 95% CI, 0.50–0.64, <italic>P</italic> &lt; 0.00001) through fixed effect model.</p><p><bold>Conclusion:</bold> The result of our study suggested that hay fever may significantly decrease the risk of pancreatic cancer.</p>