AUTHOR=Schneider Deborah , Bouhali Florence , Richter Caroline G. , Costache Radu , Costache Catalina , Kirchhoffer Kaitlyn , Sheth Vatsa , MacDonald Ibo , Hoeft Fumiko 

TITLE=Perinatal influences on academic achievement and the developing brain: a scoping systematic review

JOURNAL=Frontiers in Psychology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2024.1352241

DOI=10.3389/fpsyg.2024.1352241

ISSN=1664-1078

ABSTRACT=<sec id="sec1"><title>Introduction and methods</title><p>In this PRISMA-compliant systematic review, we identify and synthesize the findings of research in which neuroimaging and assessments of achievement have been used to examine the relationships among aspects of developmental programming, neurodevelopment, and achievement in reading and mathematics.</p></sec><sec id="sec2"><title>Results</title><p>Forty-seven studies met inclusion criteria. The majority examined the impact of prematurity (<italic>n</italic> = 32) and prenatal alcohol exposure (<italic>n</italic> = 13). Several prematurity studies reported a positive correlation between white-matter integrity of callosal fibers and executive functioning and/or achievement, and white matter properties were consistently associated with cognitive and academic performance in preterm and full-term children. Volumetric studies reported positive associations between academic and cognitive abilities and white and gray matter volume in regions such as the insula, putamen, and prefrontal lobes. Functional MRI studies demonstrated increased right-hemispheric language processing among preterm children. Altered activation of the frontoparietal network related to numerical abilities was also reported. Prenatal alcohol exposure studies reported alterations in white matter microstructure linked to deficits in cognitive functioning and academic achievement, including mathematics, reading, and vocabulary skills. Volumetric studies reported reductions in cerebral, cerebellar, and subcortical gray matter volumes associated with decreased scores on measures of executive functioning, attention, working memory, and academic performance. Functional MRI studies demonstrated broad, diffuse activation, reduced activation in canonical regions, and increased activation in non-canonical regions during numeric tasks.</p></sec><sec id="sec3"><title>Discussion</title><p>A preponderance of studies linked prematurity and prenatal alcohol exposure to altered neurodevelopmental processes and suboptimal academic achievement. Limitations and recommendations for future research are discussed.</p></sec><sec><title>Systematic review registration</title><p>Identifier: DOI <ext-link xlink:href="https://doi.org/10.17605/OSF.IO/ZAN67" ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink">10.17605/OSF.IO/ZAN67</ext-link>.</p></sec>