AUTHOR=Zheng Nanxi , Ou Yangpan , Li Huabing , Liu Feng , Xie Guojun , Li Ping , Lang Bing , Guo Wenbin 

TITLE=Shared and differential fractional amplitude of low-frequency fluctuation patterns at rest in major depressive disorders with or without sleep disturbance

JOURNAL=Frontiers in Psychology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2023.1153335

DOI=10.3389/fpsyg.2023.1153335

ISSN=1664-1078

ABSTRACT=<sec><title>Objective</title><p>Sleep disturbances (SD) are commonly found in patients with major depressive disorder (MDD). This study aims to explore the influence of SD symptoms on clinical characteristics in patients with MDD and to investigate the shared and distinct fractional amplitude of low-frequency fluctuation (fALFF) patterns in these patients with or without SD symptoms.</p></sec><sec><title>Methods</title><p>Twenty-four MDD patients with SD symptoms (<italic>Pa_s</italic>), 33 MDD patients without SD symptoms (<italic>Pa_ns</italic>) and 32 healthy controls (HCs) were included in this study. The fALFF and correlation analyses were applied to analyze the features of imaging and clinical data.</p></sec><sec><title>Results</title><p><italic>Pa_s</italic> showed more severe anxiety and depression than <italic>Pa_ns</italic>. Compared with <italic>Pa_ns</italic>, <italic>Pa_s</italic> exhibited increased fALFF value in the left precuneus. Patients shared abnormal fALFF in the frontal-occipital brain regions. There was a positive correlation between fALFF values of the left precuneus and sleep disturbance scores (<italic>r</italic> = 0.607, <italic>p</italic> = 0.0000056734) in all patients in addition to a negative correlation between fALFF values of the left MOG/cuneus and HAMD-17 total scores (<italic>r</italic> = −0.595, <italic>p</italic> = 0.002141) in <italic>Pa_s</italic>. The receiver operating characteristic (ROC) results of the fALFF could be used to discriminate <italic>Pa_s</italic> from <italic>Pa_ns</italic> with a specificity of 72.73% and a sensitivity of 70.83%.</p></sec><sec><title>Conclusion</title><p><italic>Pa_s</italic> displayed more serious anxiety and depression symptoms. Patients shared abnormal fALFF in the frontal-occipital brain regions, which may be a common characteristic for MDD. And increased fALFF value in the left precuneus might be a specific neuroimaging feature of MDD patients with SD symptoms.</p></sec>