AUTHOR=Ávila-Villanueva Marina , Marcos Dolado Alberto , Gómez-Ramírez Jaime , Fernández-Blázquez Miguel 

TITLE=Brain Structural and Functional Changes in Cognitive Impairment Due to Alzheimer’s Disease

JOURNAL=Frontiers in Psychology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2022.886619

DOI=10.3389/fpsyg.2022.886619

ISSN=1664-1078

ABSTRACT=<p>Cognitive neuropsychology seeks a potential alignment between structural and functional brain features to explain physiological or pathological processes, such as Alzheimer’s disease (AD). Several structural and functional brain changes occurring during the disease, including cognitive impairment, are found at the end of the patient’s life, but we need to know more about what happens before its onset. In order to do that, we need earlier biomarkers at preclinical stages, defined by those biomarkers, to prevent the cognitive impairment. In this minireview, we have tried to describe the structural and functional changes found at different stages during AD, focusing on those features taking place before clinical diagnosis.</p>