AUTHOR=Zhang Shun , Zhang Jinghuan 

TITLE=The Association of DRD2 with Insight Problem Solving

JOURNAL=Frontiers in Psychology

VOLUME=7

YEAR=2016

URL=https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2016.01865

DOI=10.3389/fpsyg.2016.01865

ISSN=1664-1078

ABSTRACT=<p>Although the insight phenomenon has attracted great attention from psychologists, it is still largely unknown whether its variation in well-functioning human adults has a genetic basis. Several lines of evidence suggest that genes involved in dopamine (DA) transmission might be potential candidates. The present study explored for the first time the association of dopamine D2 receptor gene (<italic>DRD2</italic>) with insight problem solving. Fifteen single-nucleotide polymorphisms (SNPs) covering <italic>DRD2</italic> were genotyped in 425 unrelated healthy Chinese undergraduates, and were further tested for association with insight problem solving. Both single SNP and haplotype analysis revealed several associations of <italic>DRD2</italic> SNPs and haplotypes with insight problem solving. In conclusion, the present study provides the first evidence for the involvement of <italic>DRD2</italic> in insight problem solving, future studies are necessary to validate these findings.</p>