AUTHOR=Messina Giovanni , Dalia Carmine , Tafuri Domenico , Monda Vincenzo , Palmieri Filomena , Dato Amelia , Russo Angelo , De Blasio Saverio , Messina Antonietta , De Luca Vincenzo , Chieffi Sergio , Monda Marcellino TITLE=Orexin-A controls sympathetic activity and eating behavior JOURNAL=Frontiers in Psychology VOLUME=5 YEAR=2014 URL=https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2014.00997 DOI=10.3389/fpsyg.2014.00997 ISSN=1664-1078 ABSTRACT=

It is extremely important for the health to understand the regulatory mechanisms of energy expenditure. These regulatory mechanisms play a central role in the pathogenesis of body weight alteration. The hypothalamus integrates nutritional information derived from all peripheral organs. This region of the brain controls hormonal secretions and neural pathways of the brainstem. Orexin-A is a hypothalamic neuropeptide involved in the regulation of feeding behavior, sleep-wakefulness rhythm, and neuroendocrine homeostasis. This neuropeptide is involved in the control of the sympathetic activation, blood pressure, metabolic status, and blood glucose level. This minireview focuses on relationship between the sympathetic nervous system and orexin-A in the control of eating behavior and energy expenditure. The “thermoregulatory hypothesis” of food intake is analyzed, underlining the role played by orexin-A in the control of food intake related to body temperature. Furthermore, the paradoxical eating behavior induced orexin-A is illustrated in this minireview.