AUTHOR=Pendergast Julie S., Branecky Katrina L., Huang Roya , Niswender Kevin D., Yamazaki Shin TITLE=Wheel-running activity modulates circadian organization and the daily rhythm of eating behavior JOURNAL=Frontiers in Psychology VOLUME=Volume 5 - 2014 YEAR=2014 URL=https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2014.00177 DOI=10.3389/fpsyg.2014.00177 ISSN=1664-1078 ABSTRACT=
Consumption of high-fat diet acutely alters the daily rhythm of eating behavior and circadian organization (the phase relationship between oscillators in central and peripheral tissues) in mice. Voluntary wheel-running activity counteracts the obesogenic effects of high-fat diet and also modulates circadian rhythms in mice. In this study, we sought to determine whether voluntary wheel-running activity could prevent the proximate effects of high-fat diet consumption on circadian organization and behavioral rhythms in mice. Mice were housed with locked or freely rotating running wheels and fed chow or high-fat diet for 1 week and rhythms of locomotor activity, eating behavior, and molecular timekeeping (PERIOD2::LUCIFERASE luminescence rhythms) in