ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Molecular Psychiatry
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1589374
Exosomal microRNA signatures in youth at clinical high risk for bipolar disorder
Provisionally accepted
- Peking University Sixth Hospital, Beijing, China
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Introduction: Individuals at clinical high risk for bipolar disorder (CHR-BD) experienced insufficient recognition. Little is known regarding the association between exosome miRNA profile and bipolar disorder (BD) risk.Materials and Methods: Twenty youth at CHR-BD, 21 patients with BD, and 24 healthy controls were recruited in this study. Exosomal small RNA sequencing was undertaken in the plasma sample of the participants. Using machine-learning algorithms, target miRNAs were selected from differentially expressed candidates. Predictive models were built and tested on validation set.Results: The study identified two miRNAs that showed significantly differential expression between the CHR-BD group and the HC group: hsa-miR-184 (log2FC = 4.22, P = 1.49E-04) and hsa-miR-196a-5p (log2FC = 4.75, P = 3.56E-04). Random forest and eXtreme Gradient Boosting jointly selected two overlapping miRNAs: hsa-miR-1908-3p and hsa-miR-412-5p. XGBoost outperformed the RF model with higher AUCs (BD group: 0.71 vs 0.71, CHR-BD group: 0.74 vs 0.72, HC group: 0.60 vs 0.57).The study identified four target miRNAs involved in neuroimmunity and neuronal plasticity, supported by literature linking these miRNAs to neuropsychiatric diseases, suggesting their potential as biomarkers for early BD. Future research should integrate additional biomarkers for improved discriminative performance.
Keywords: Bipolar Disorder, Clinical high risk, miRNA, exosome, biomarker
Received: 07 Mar 2025; Accepted: 14 Apr 2025.
Copyright: © 2025 Meng, Zhang, Xu, Ma, Zhou, Ma, Ma, Yu and Guan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lili Guan, Peking University Sixth Hospital, Beijing, China
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