AUTHOR=Fiorillo Andrea , Demyttenaere Koen , Martiadis Vassilis , Martinotti Giovanni TITLE=Editorial: Treatment resistant depression (TRD): epidemiology, clinic, burden and treatment JOURNAL=Frontiers in Psychiatry VOLUME=16 YEAR=2025 URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1588902 DOI=10.3389/fpsyt.2025.1588902 ISSN=1664-0640