ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Mood Disorders
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1580151
The correlation between systemic immune-inflammation index and major depression in patients with depression
Provisionally accepted
- 1Xiamen Xianyue Hospital, Xiamen, China
- 2Zhongshan Hospital, Xiamen University, Xiamen, Fujian Province, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
To explore the relationship between the systemic immune-inflammation index (SII) and the severity of depression.Methods: This retrospective study included 750 patients who were hospitalized at Xiamen Xianyue Hospital and diagnosed with depression from January 2022 to December 2023. The SII was defined as the platelet count × neutrophil count / lymphocyte count. The participants were divided into a mild to moderate depression group (299 patients) and a major depression group (451 patients). Univariate and multivariate Logistic regression analysis, subgroup analysis, sensitivity analysis, and receiver operating characteristic (ROC) curve analysis were used to explore the correlation between the SII and the severity of depression.Results: According to the multivariate Logistic regression analysis, the SII was independently associated with the risk of major depression (P < 0.05). For every 1-unit and 1-standard-deviation increase in the SII, the risk of major depression increased by
Keywords: Systemic immune-inflammatory index, Depression, severity, major depression, Correlation
Received: 21 Feb 2025; Accepted: 15 Apr 2025.
Copyright: © 2025 Bai, Fang, Dai, Zhang and You. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Pan You, Xiamen Xianyue Hospital, Xiamen, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.