CASE REPORT article
Front. Psychiatry
Sec. Psychological Therapy and Psychosomatics
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1576740
Progressive episodes of recurrent syncope due to postural orthostatic tachycardia syndrome truncated by paroxetine: A case report
Provisionally accepted
Hai Liang*
Chen LiangLihua ChenJiayang FangYongxin YiYidong GaoXiang HuangXi ChenTing LiuWei PanLufeng Yin- Third Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, China
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Postural orthostatic tachycardia syndrome (POTS) is characterized by an increased heart rate upon standing, resulting from abnormal autonomic responses that trigger symptoms when transitioning to an upright position. This syndrome predominantly manifests in late adolescence and early adulthood, with a higher prevalence observed in women. It is commonly triggered by viral infections, pregnancy, surgical procedures, or significant psychological stress. The condition presents with a wide range of symptoms, and the precise etiology of which remains unidentified. A 17-year-old woman with recurrent syncope was admitted to the hospital multiple times. Symptoms resolved rapidly following the initiation of paroxetine, a selective serotonin reuptake inhibitor (SSRI). Preliminary analysis indicated a potential shared pathophysiological basis between POTS and anxiety disorders, with norepinephrine transporter proteins emerging as a significant therapeutic target for both conditions.
Keywords: Postural Orthostatic Tachycardia Syndrome, Paroxetine, Recurrent syncope, Anxiety Disorders, norepinephrine transporter proteins
Received: 14 Feb 2025; Accepted: 22 Apr 2025.
Copyright: © 2025 Liang, Liang, Chen, Fang, Yi, Gao, Huang, Chen, Liu, Pan and Yin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hai Liang, Third Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, China
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