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ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Psychopathology
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1557451
This article is part of the Research Topic Neuroimaging Methods for the Pathogenesis of Children and Adolescents with Affective Disorders View all articles
Higher levels of total cholesterol/high-density lipoprotein cholesterol ratios are associated with an increased risk of suicidal behavior in children and adolescents with depressive disorders
Provisionally accepted
Nana Sun 1
Zhiwei Liu 2* Liang Sun 2 Feng Sun 2 Longlong Sun 2 Jingjing Zhang 2 Rongchun Yang 2
Gaofeng Yao 2 Yun Liu 2*- 1 Affiliated Psychological Hospital of Anhui Medical University, Hefei, China
- 2 The Third People's Hospital of Fuyang, Fuyang, China
Objective: To explore the prevalence of suicidal ideation (SI) and suicidal attempt (SA) in inpatients with childhood and adolescent depressive disorders and the relationship between triglyceride/high-density lipoprotein cholesterol (TG/HDL-C), total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C) ratios and SI, SA. Methods: A study was conducted involving 515 pediatric patients diagnosed with depressive disorders at the Third People's Hospital of Fuyang. This research primarily focused on gathering basic demographic and clinical data. Through employing methods such as correlation analysis and logistic regression, the study aimed to identify factors linked to SI and SA among these individuals. Results: The prevalence of SI and SA was 20.0% (103/515) and 9.1% (47/515). Binary logistic regression highlighted several independent predictors for SI. A notable increase in the likelihood of SI was observed with an increase in the number of hospitalizations (Odds Ratio [OR]=1.65, P=0.025), a heightened TC/HDL-C ratio (OR=1.72, P=0.002), an escalated antidepressant dosage (OR=1.02, P=0.029), and elevated HAMD scores (OR=1.04, P=0.003). For SA, critical independent associated factors identified were an increased number of hospitalizations (OR=2.71, P<0.001), a higher TC/HDL-C ratio (OR=1.69, P=0.002), and greater HAMD scores (OR=1.06, P=0.003), particularly in children and adolescents diagnosed with depressive disorders. Conclusion: These findings suggest that monitoring lipid profiles, particularly the TC/HDL-C ratio, alongside careful management of antidepressant dosages and close observation of depressive symptoms, could be crucial in mitigating suicidal risks among this vulnerable population.
Keywords: Depressive Disorder, Suicidal Ideation, suicide attempt, TG/HDL-C, TC/HDL-C, Associated factors
Received: 08 Jan 2025; Accepted: 24 Feb 2025.
Copyright: © 2025 Sun, Liu, Sun, Sun, Sun, Zhang, Yang, Yao and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhiwei Liu, The Third People's Hospital of Fuyang, Fuyang, China
Yun Liu, The Third People's Hospital of Fuyang, Fuyang, China
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