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ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Schizophrenia
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1552451
This article is part of the Research Topic Unraveling the Nexus of Inflammatory Biomarkers and Cognitive Dysfunction in Schizophrenia: Implications for Treatment and Disease Progression View all 4 articles
Neutrophil-to-lymphocyte ratio; Plateletto-lymphocyte ratio; systemic immuneinflammatory Index: inflammatory indicators of cognitive impairment in schizophrenia patients
Provisionally accepted- 1 Shanghai Minhang Mental Health Center, Shanghai, China
- 2 Shanghai Mental Health Center, Shanghai, China
- 3 Psychiatric Clinic, Shanghai Mental Health Center, Shanghai, Shanghai Municipality, China
In the study , we aim to develop the correlation between cognitive impairment (CI) and inflammatory indicators such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammatory index (SII) in schizophrenia patients by collecting hospitalized stable adult schizophrenic patients, collecting general and clinical data (blood routine, etc.), and assessing the cognitive function of the patients.The patients were categorized into CN(Cognitive normal, CN)and CI groups based on the Mini-Mental State Examination (MMSE) scale scores, and then the patients in the CI group were categorized into mild CI, moderate CI, and severe CI groups. Comparing the differences in the values of NLR, PLR, and SII between the CN group and the CI group, as well as among the patients in different CI groups, and analyzing the relationship between the values of NLR, PLR, and SII and the mechanism of CI in schizophrenia.
Keywords: cognitive impairment, Neutrophil-to-lymphocyte ratio, platelet-tolymphocyte ratio, Systemic immune-inflammatory index, Schizophrenia
Received: 28 Dec 2024; Accepted: 24 Mar 2025.
Copyright: © 2025 Chen, Wang, Ning, Pan and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ke Chen, Shanghai Minhang Mental Health Center, Shanghai, China
Weibo Zhang, Shanghai Minhang Mental Health Center, Shanghai, China
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